Ghrelin Therapy Improves Survival after Whole-Body Ionizing Irradiation or Combined with Burn or Wound: Amelioration of Leukocytopenia, Thrombocytopenia, Splenomegaly, and Bone Marrow Injury
Joint Authors
Kiang, Juliann G.
Liao, Pei-Jyun
Elliott, Thomas B.
Gorbunov, Nikolai V.
Zhai, Min
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Exposure to ionizing radiation alone (RI) or combined with traumatic tissue injury (CI) is a crucial life-threatening factor in nuclear and radiological events.
In our laboratory, mice exposed to 60Co-γ-photon radiation (9.5 Gy, 0.4 Gy/min, bilateral) followed by 15% total-body-surface-area skin wounds (R-W CI) or burns (R-B CI) experienced an increment of ≥18% higher mortality over a 30-day observation period compared to RI alone.
CI was accompanied by severe leukocytopenia, thrombocytopenia, erythropenia, and anemia.
At the 30th day after injury, numbers of WBC and platelets still remained very low in surviving RI and CI mice.
In contrast, their RBC, hemoglobin, and hematocrit were recovered towards preirradiation levels.
Only RI induced splenomegaly.
RI and CI resulted in bone-marrow cell depletion.
In R-W CI mice, ghrelin (a hunger-stimulating peptide) therapy increased survival, mitigated body-weight loss, accelerated wound healing, and increased hematocrit.
In R-B CI mice, ghrelin therapy increased survival and numbers of neutrophils, lymphocytes, and platelets and ameliorated bone-marrow cell depletion.
In RI mice, this treatment increased survival, hemoglobin, and hematocrit and inhibited splenomegaly.
Our novel results are the first to suggest that ghrelin therapy effectively improved survival by mitigating CI-induced leukocytopenia, thrombocytopenia, and bone-marrow injury or the RI-induced decreased hemoglobin and hematocrit.
American Psychological Association (APA)
Kiang, Juliann G.& Zhai, Min& Liao, Pei-Jyun& Elliott, Thomas B.& Gorbunov, Nikolai V.. 2014. Ghrelin Therapy Improves Survival after Whole-Body Ionizing Irradiation or Combined with Burn or Wound: Amelioration of Leukocytopenia, Thrombocytopenia, Splenomegaly, and Bone Marrow Injury. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1046970
Modern Language Association (MLA)
Kiang, Juliann G.…[et al.]. Ghrelin Therapy Improves Survival after Whole-Body Ionizing Irradiation or Combined with Burn or Wound: Amelioration of Leukocytopenia, Thrombocytopenia, Splenomegaly, and Bone Marrow Injury. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1046970
American Medical Association (AMA)
Kiang, Juliann G.& Zhai, Min& Liao, Pei-Jyun& Elliott, Thomas B.& Gorbunov, Nikolai V.. Ghrelin Therapy Improves Survival after Whole-Body Ionizing Irradiation or Combined with Burn or Wound: Amelioration of Leukocytopenia, Thrombocytopenia, Splenomegaly, and Bone Marrow Injury. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1046970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046970