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The Role of Nrf2-Mediated Pathway in Cardiac Remodeling and Heart Failure
Joint Authors
Zheng, Yang
Zhou, Shanshan
Sun, Wanqing
Zhang, Zhiguo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Heart failure (HF) is frequently the consequence of sustained, abnormal neurohormonal, and mechanical stress and remains a leading cause of death worldwide.
The key pathophysiological process leading to HF is cardiac remodeling, a term referring to maladaptation to cardiac stress at the molecular, cellular, tissue, and organ levels.
HF and many of the conditions that predispose one to HF are associated with oxidative stress.
Increased generation of reactive oxygen species (ROS) in the heart can directly lead to increased necrosis and apoptosis of cardiomyocytes which subsequently induce cardiac remodeling and dysfunction.
Nuclear factor-erythroid-2- (NF-E2-) related factor 2 (Nrf2) is a transcription factor that controls the basal and inducible expression of a battery of antioxidant genes and other cytoprotective phase II detoxifying enzymes that are ubiquitously expressed in the cardiovascular system.
Emerging evidence has revealed that Nrf2 and its target genes are critical regulators of cardiovascular homeostasis via the suppression of oxidative stress, which is the key player in the development and progression of HF.
The purpose of this review is to summarize evidence that activation of Nrf2 enhances endogenous antioxidant defenses and counteracts oxidative stress-associated cardiac remodeling and HF.
American Psychological Association (APA)
Zhou, Shanshan& Sun, Wanqing& Zhang, Zhiguo& Zheng, Yang. 2014. The Role of Nrf2-Mediated Pathway in Cardiac Remodeling and Heart Failure. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1046983
Modern Language Association (MLA)
Zhou, Shanshan…[et al.]. The Role of Nrf2-Mediated Pathway in Cardiac Remodeling and Heart Failure. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1046983
American Medical Association (AMA)
Zhou, Shanshan& Sun, Wanqing& Zhang, Zhiguo& Zheng, Yang. The Role of Nrf2-Mediated Pathway in Cardiac Remodeling and Heart Failure. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1046983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046983