Anticonvulsant and Antioxidant Effects of Tilia americana var. mexicana and Flavonoids Constituents in the Pentylenetetrazole-Induced Seizures
Joint Authors
Cárdenas-Rodríguez, Noemí
González-Trujano, M. E.
Aguirre-Hernández, E.
Ruíz-García, Matilde
Coballase-Urrutia, Elvia
Sampieri, Aristides III
Carmona-Aparicio, Liliana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tilia genus is commonly used around the world for its central nervous system properties; it is prepared as tea and used as tranquilizing, anticonvulsant, and analgesic.
In this study, anticonvulsant activity of the Tilia americana var.
mexicana inflorescences and leaves was investigated by evaluating organic and aqueous extracts (100, 300, and 600 mg/kg, i.p.) and some flavonoids in the pentylenetetrazole-induced seizures in mice.
Moreover, antioxidant effect of these extracts and flavonoids was examined in an in vitro study by using spectrophotometric technique.
Significant activity was observed in the methanol extract from inflorescences.
An HPLC analysis of the methanol extract from inflorescences and leaves of Tilia allowed demonstrating the respective presence of some partial responsible flavonoid constituents: quercetin (20.09 ± 1.20 μg/mg and 3.39 ± 0.10 μg/mg), rutin (3.52 ± 0.21 μg/mg and 8.94 ± 0.45 μg/mg), and isoquercitrin (1.74 ± 0.01 μg/mg and 1.24 ± 0.13 μg/mg).
In addition, significant but different antioxidant properties were obtained among the flavonoids and the extracts investigated.
Our results provide evidence of the anticonvulsant activity of Tilia reinforcing its utility for central nervous system diseases whose mechanism of action might involve partial antioxidant effects due to the presence of flavonoids.
American Psychological Association (APA)
Cárdenas-Rodríguez, Noemí& González-Trujano, M. E.& Aguirre-Hernández, E.& Ruíz-García, Matilde& Sampieri, Aristides III& Coballase-Urrutia, Elvia…[et al.]. 2014. Anticonvulsant and Antioxidant Effects of Tilia americana var. mexicana and Flavonoids Constituents in the Pentylenetetrazole-Induced Seizures. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047011
Modern Language Association (MLA)
Cárdenas-Rodríguez, Noemí…[et al.]. Anticonvulsant and Antioxidant Effects of Tilia americana var. mexicana and Flavonoids Constituents in the Pentylenetetrazole-Induced Seizures. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047011
American Medical Association (AMA)
Cárdenas-Rodríguez, Noemí& González-Trujano, M. E.& Aguirre-Hernández, E.& Ruíz-García, Matilde& Sampieri, Aristides III& Coballase-Urrutia, Elvia…[et al.]. Anticonvulsant and Antioxidant Effects of Tilia americana var. mexicana and Flavonoids Constituents in the Pentylenetetrazole-Induced Seizures. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047011
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047011