![](/images/graphics-bg.png)
Antiaging Properties of a Grape-Derived Antioxidant Are Regulated by Mitochondrial Balance of Fusion and Fission Leading to Mitophagy Triggered by a Signaling Network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN
Joint Authors
Das, Somak
Mitrovsky, Goran
Vasanthi, Hannah R.
Das, Dipak K.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
It was proposed that resveratrol, a polyphenolic antioxidant and a calorie restriction mimetic could promote longevity but subsequent studies could not prove this.
The original proposal was based on the fact that a grape-derived antioxidant could activate the antiaging gene Sirt1.
Most studies agree that indeed grape activates Sirt1, but a question remains whether Sirt1 is the cause or consequence of resveratrol treatment.
Subsequently, mitochondrial Sirt3 was found to be activated.
The present study on ischemic reperfusion (I/R) in rat hearts demonstrates that Foxo3a is activated subsequent to Sirt3 activation, which then activates PINK1.
PINK1 potentiates activation of PARKIN leading to the activation of mitochondrial fission and mitophagy.
Confocal microscopy conclusively shows the coexistence of Sirt3 with Foxo3a and Foxo3a with PINK1 and PARKIN.
Mitophagy was demonstrated both by confocal microscopy and transmission electron microscopy.
Western blot analyses data are consistent with the results of confocal microscopy.
It appears that the grape-derived antioxidant modifies the intracellular environment by changing the oxidizing milieu into a reducing milieu and upregulating intracellular glutathione, potentiates a signal transduction cascade consisting of Sirt1/Sirt3-Foxo3a-PINK1-PARKIN-mitochondrial fusion fission-mitophagy that leads to cardioprotection, and paves the way to an anti-aging environment.
American Psychological Association (APA)
Das, Somak& Mitrovsky, Goran& Vasanthi, Hannah R.& Das, Dipak K.. 2013. Antiaging Properties of a Grape-Derived Antioxidant Are Regulated by Mitochondrial Balance of Fusion and Fission Leading to Mitophagy Triggered by a Signaling Network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047015
Modern Language Association (MLA)
Das, Somak…[et al.]. Antiaging Properties of a Grape-Derived Antioxidant Are Regulated by Mitochondrial Balance of Fusion and Fission Leading to Mitophagy Triggered by a Signaling Network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1047015
American Medical Association (AMA)
Das, Somak& Mitrovsky, Goran& Vasanthi, Hannah R.& Das, Dipak K.. Antiaging Properties of a Grape-Derived Antioxidant Are Regulated by Mitochondrial Balance of Fusion and Fission Leading to Mitophagy Triggered by a Signaling Network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047015