Aging Aggravates Nitrate-Mediated ROSRNS Changes
Joint Authors
Liu, Jing-Hua
Lau, Wayne Bond
Chen, Lifen
Cheng, Shujuan
Wang, Le Feng
Liu, Jing Hua
Fan, Qian
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nitrates are the most frequently prescribed and utilized drugs worldwide.
The elderly are a major population receiving nitrate therapy.
Both nitrates and aging can increase in vivo reactive oxygen species (ROS) and reactive nitrogen species (RNS).
To date, the effects of aging upon nitrate-induced ROS/RNS alteration are unknown.
The present study tested the effects of aging upon nitrate-induced ROS/RNS alteration in vivo.
32 adults and 43 elderly unstable angina (UA) patients were subjected to 48 hours of isosorbide dinitrate intravenous injection (50 μg/minutes) in this clinical study.
Blood samples were obtained at baseline and conclusion.
Outcome measures of oxidative stress included plasma malondialdehyde (MDA), myeloperoxidase (MPO), and reduced glutathione (GSH).
Plasma concentrations of NOx and nitrotyrosine served as markers of RNS.
Because of the significant differences in basic clinical characters between adults and the elderly, we designed an additional experiment determining ROS/RNS stress in rat cardiac tissue.
Additionally, rat thoracic aortic NOS activity served as a marker indicating endothelial function.
Our study demonstrated that nitrate therapy significantly increased in vivo ROS/RNS stress in the elderly compared to adult patients, confirmed by animal data.
Decreased NOS activity was observed in old rats.
Taken together, the present study’s data suggests a synergism between nitrate treatment and the aging process.
American Psychological Association (APA)
Fan, Qian& Chen, Lifen& Cheng, Shujuan& Lau, Wayne Bond& Liu, Jing-Hua& Wang, Le Feng…[et al.]. 2014. Aging Aggravates Nitrate-Mediated ROSRNS Changes. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047020
Modern Language Association (MLA)
Fan, Qian…[et al.]. Aging Aggravates Nitrate-Mediated ROSRNS Changes. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1047020
American Medical Association (AMA)
Fan, Qian& Chen, Lifen& Cheng, Shujuan& Lau, Wayne Bond& Liu, Jing-Hua& Wang, Le Feng…[et al.]. Aging Aggravates Nitrate-Mediated ROSRNS Changes. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047020