Oxidative Modification of Proteins in Pediatric Cystic Fibrosis with Bacterial Infections
Joint Authors
Bartosz, G.
Galiniak, Sabina
Rachel, Marta
Sadowska-Bartosz, Izabela
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Pseudomonas aeruginosa and Staphylococcus aureus cause chronic lung infection in cystic fibrosis (CF) patients, inducing chronic oxidative stress.
Several markers of plasma protein oxidative damage and glycoxidation and activities of erythrocyte antioxidant enzymes have been compared in stable CF patients chronically infected with Pseudomonas aeruginosa (n=12) and Staphylococcus aureus (n=10) in relation to healthy subjects (n=11).
Concentration of nitric oxide was also measured in the exhaled air from the lower respiratory tract of patients with CF.
Elevated glycophore (4.22 ± 0.91 and 4.19 ± 1.04 versus control 3.18 ± 0.53 fluorescence units (FU)/mg protein; P<0.05) and carbonyl group levels (1.9 ± 0.64, 1.87 ± 0.45 versus control 0.94 ± 0.19 nmol/mg protein; P<0.05) as well as increased glutathione S-transferase activity (2.51 ± 0.88 and 2.57 ± 0.79 U/g Hb versus 0.77 ± 0.16 U/g Hb; P<0.05) were noted in Pseudomonas aeruginosa and Staphylococcus aureus infected CF.
Kynurenine level (4.91 ± 1.22 versus 3.89 ± 0.54 FU/mg protein; P<0.05) was elevated only in Staphylococcus aureus infected CF.
These results confirm oxidative stress in CF and demonstrate the usefulness of the glycophore level and protein carbonyl groups as markers of oxidative modifications of plasma proteins in this disease.
American Psychological Association (APA)
Sadowska-Bartosz, Izabela& Galiniak, Sabina& Bartosz, G.& Rachel, Marta. 2014. Oxidative Modification of Proteins in Pediatric Cystic Fibrosis with Bacterial Infections. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047022
Modern Language Association (MLA)
Sadowska-Bartosz, Izabela…[et al.]. Oxidative Modification of Proteins in Pediatric Cystic Fibrosis with Bacterial Infections. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047022
American Medical Association (AMA)
Sadowska-Bartosz, Izabela& Galiniak, Sabina& Bartosz, G.& Rachel, Marta. Oxidative Modification of Proteins in Pediatric Cystic Fibrosis with Bacterial Infections. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047022