Metallothionein-II Inhibits Lipid Peroxidation and Improves Functional Recovery after Transient Brain Ischemia and Reperfusion in Rats
Joint Authors
Montes, Sergio
Méndez-Armenta, Marisela
Diaz-Ruiz, Araceli
Vacio-Adame, Patricia
Monroy-Noyola, Antonio
Ortiz-Plata, Alma
Ríos, Camilo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
After transient cerebral ischemia and reperfusion (I/R), damaging mechanisms, such as excitotoxicity and oxidative stress, lead to irreversible neurological deficits.
The induction of metallothionein-II (MT-II) protein is an endogenous mechanism after I/R.
Our aim was to evaluate the neuroprotective effect of MT-II after I/R in rats.
Male Wistar rats were transiently occluded at the middle cerebral artery for 2 h, followed by reperfusion.
Rats received either MT (10 μg per rat i.p.) or vehicle after ischemia.
Lipid peroxidation (LP) was measured 22 h after reperfusion in frontal cortex and hippocampus; also, neurological deficit was evaluated after ischemia, using the Longa scoring scale.
Infarction area was analyzed 72 hours after ischemia.
Results showed increased LP in frontal cortex (30.7%) and hippocampus (26.4%), as compared to control group; this effect was fully reversed by MT treatment.
Likewise, we also observed a diminished neurological deficit assessed by the Longa scale in those animals treated with MT compared to control group values.
The MT-treated group showed a significant ( P < 0.05 ) reduction of 39.9% in the infarction area, only at the level of hippocampus, as compared to control group.
Results suggest that MT-II may be a novel neuroprotective treatment to prevent ischemia injury.
American Psychological Association (APA)
Diaz-Ruiz, Araceli& Vacio-Adame, Patricia& Monroy-Noyola, Antonio& Méndez-Armenta, Marisela& Ortiz-Plata, Alma& Montes, Sergio…[et al.]. 2014. Metallothionein-II Inhibits Lipid Peroxidation and Improves Functional Recovery after Transient Brain Ischemia and Reperfusion in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047034
Modern Language Association (MLA)
Diaz-Ruiz, Araceli…[et al.]. Metallothionein-II Inhibits Lipid Peroxidation and Improves Functional Recovery after Transient Brain Ischemia and Reperfusion in Rats. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1047034
American Medical Association (AMA)
Diaz-Ruiz, Araceli& Vacio-Adame, Patricia& Monroy-Noyola, Antonio& Méndez-Armenta, Marisela& Ortiz-Plata, Alma& Montes, Sergio…[et al.]. Metallothionein-II Inhibits Lipid Peroxidation and Improves Functional Recovery after Transient Brain Ischemia and Reperfusion in Rats. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047034