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The Attenuation of Moutan Cortex on Oxidative Stress for Renal Injury in AGEs-Induced Mesangial Cell Dysfunction and Streptozotocin-Induced Diabetic Nephropathy Rats
Joint Authors
Zhang, Minghua
Feng, Liang
Gu, Junfei
Ma, Liang
Qin, Dong
Wu, Chan
Jia, Xiaobin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Oxidative stress (OS) has been regarded as one of the major pathogeneses of diabetic nephropathy (DN) through damaging kidney which is associated with renal cells dysfunction.
The aim of this study was to investigate whether Moutan Cortex (MC) could protect kidney function against oxidative stress in vitro or in vivo.
The compounds in MC extract were analyzed by HPLC-ESI-MS.
High-glucose-fat diet and STZ (30 mg kg−1) were used to induce DN rats model, while 200 μ g mL−1 AGEs were for HBZY-1 mesangial cell damage.
The treatment with MC could significantly increase the activity of SOD, glutathione peroxidase (GSH-PX), and catalase (CAT).
However, lipid peroxidation malondialdehyde (MDA) was reduced markedly in vitro or in vivo.
Furthermore, MC decreased markedly the levels of blood glucose, serum creatinine, and urine protein in DN rats.
Immunohistochemical assay showed that MC downregulated significantly transforming growth factor beta 2 (TGF- β 2) protein expression in renal tissue.
Our data provided evidence to support this fact that MC attenuated OS in AGEs-induced mesangial cell dysfunction and also in high-glucose-fat diet and STZ-induced DN rats.
American Psychological Association (APA)
Zhang, Minghua& Feng, Liang& Gu, Junfei& Ma, Liang& Qin, Dong& Wu, Chan…[et al.]. 2014. The Attenuation of Moutan Cortex on Oxidative Stress for Renal Injury in AGEs-Induced Mesangial Cell Dysfunction and Streptozotocin-Induced Diabetic Nephropathy Rats. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047040
Modern Language Association (MLA)
Zhang, Minghua…[et al.]. The Attenuation of Moutan Cortex on Oxidative Stress for Renal Injury in AGEs-Induced Mesangial Cell Dysfunction and Streptozotocin-Induced Diabetic Nephropathy Rats. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1047040
American Medical Association (AMA)
Zhang, Minghua& Feng, Liang& Gu, Junfei& Ma, Liang& Qin, Dong& Wu, Chan…[et al.]. The Attenuation of Moutan Cortex on Oxidative Stress for Renal Injury in AGEs-Induced Mesangial Cell Dysfunction and Streptozotocin-Induced Diabetic Nephropathy Rats. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047040