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Hemin Attenuates Cisplatin-Induced Acute Renal Injury in Male Rats
Joint Authors
Al-Kahtani, Mohamed A.
Abdel-Moneim, Ashraf M.
Elmenshawy, Omar M.
El-Kersh, Mohamed A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The aim of this study is to investigate the protective effects of hemin (the heme oxygenase-1 [OH-1] inducer) against nephrotoxic effects induced by cisplatin [cis-diamminedichloroplatinum II (CP)] in male rats.
Methods.
The evaluation was performed through monitoring renal redox parameters: lipid peroxidation (LPO), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione reductase (GR), and reduced glutathione (GSH).
The work also examined renal function tests (urea and creatinine), tissue proinflammatory mediator like nitric oxide (NO), and kidney cytopathology.
Results.
A single intraperitoneal dose of CP (10 mg/kg b.w.) caused significant elevation of blood urea, serum creatinine, and renal LPO and NO, along with significant decline of the activities of GPx and GR, but renal SOD activity and GSH level were statistically insignificant as compared to control group.
Subcutaneous injection of hemin (40 µmol/kg b.w.) partially ameliorated CP-induced renal damage, based on suppression of blood urea, serum creatinine, the renal MDA and NO levels, and increased antioxidant capacity in CP-treated rats.
The results of histopathological and ultrastructural investigations supported the renoprotective effect of hemin against CP-induced acute toxicity.
Conclusion.
The induction of HO-1 by hemin is a promising approach in the treatment of CP-induced nephrotoxicity.
However, further preclinical studies are warranted to test effectiveness of CP/hemin on the outcome of tumor chemotherapy.
American Psychological Association (APA)
Al-Kahtani, Mohamed A.& Abdel-Moneim, Ashraf M.& Elmenshawy, Omar M.& El-Kersh, Mohamed A.. 2014. Hemin Attenuates Cisplatin-Induced Acute Renal Injury in Male Rats. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047042
Modern Language Association (MLA)
Al-Kahtani, Mohamed A.…[et al.]. Hemin Attenuates Cisplatin-Induced Acute Renal Injury in Male Rats. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047042
American Medical Association (AMA)
Al-Kahtani, Mohamed A.& Abdel-Moneim, Ashraf M.& Elmenshawy, Omar M.& El-Kersh, Mohamed A.. Hemin Attenuates Cisplatin-Induced Acute Renal Injury in Male Rats. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047042