Pegylated G-CSF Inhibits Blood Cell Depletion, Increases Platelets, Blocks Splenomegaly, and Improves Survival after Whole-Body Ionizing Irradiation but Not after Irradiation Combined with Burn
Joint Authors
Kiang, Juliann G.
Bolduc, David L.
Liao, Pei-Jyun
Elliott, Thomas B.
Gorbunov, Nikolai V.
Zhai, Min
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Exposure to ionizing radiation alone (radiation injury, RI) or combined with traumatic tissue injury (radiation combined injury, CI) is a crucial life-threatening factor in nuclear and radiological accidents.
As demonstrated in animal models, CI results in greater mortality than RI.
In our laboratory, we found that B6D2F1/J female mice exposed to 60Co-γ-photon radiation followed by 15% total-body-surface-area skin burns experienced an increment of 18% higher mortality over a 30-day observation period compared to irradiation alone; that was accompanied by severe cytopenia, thrombopenia, erythropenia, and anemia.
At the 30th day after injury, neutrophils, lymphocytes, and platelets still remained very low in surviving RI and CI mice.
In contrast, their RBC, hemoglobin, and hematocrit were similar to basal levels.
Comparing CI and RI mice, only RI induced splenomegaly.
Both RI and CI resulted in bone marrow cell depletion.
It was observed that only the RI mice treated with pegylated G-CSF after RI resulted in 100% survival over the 30-day period, and pegylated G-CSF mitigated RI-induced body-weight loss and depletion of WBC and platelets.
Peg-G-CSF treatment sustained RBC balance, hemoglobin levels, and hematocrits and inhibited splenomegaly after RI.
The results suggest that pegylated G-CSF effectively sustained animal survival by mitigating radiation-induced cytopenia, thrombopenia, erythropenia, and anemia.
American Psychological Association (APA)
Kiang, Juliann G.& Zhai, Min& Liao, Pei-Jyun& Bolduc, David L.& Elliott, Thomas B.& Gorbunov, Nikolai V.. 2014. Pegylated G-CSF Inhibits Blood Cell Depletion, Increases Platelets, Blocks Splenomegaly, and Improves Survival after Whole-Body Ionizing Irradiation but Not after Irradiation Combined with Burn. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047044
Modern Language Association (MLA)
Kiang, Juliann G.…[et al.]. Pegylated G-CSF Inhibits Blood Cell Depletion, Increases Platelets, Blocks Splenomegaly, and Improves Survival after Whole-Body Ionizing Irradiation but Not after Irradiation Combined with Burn. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047044
American Medical Association (AMA)
Kiang, Juliann G.& Zhai, Min& Liao, Pei-Jyun& Bolduc, David L.& Elliott, Thomas B.& Gorbunov, Nikolai V.. Pegylated G-CSF Inhibits Blood Cell Depletion, Increases Platelets, Blocks Splenomegaly, and Improves Survival after Whole-Body Ionizing Irradiation but Not after Irradiation Combined with Burn. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047044
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047044