The Emerging Role of TR α 1 in Cardiac Repair: Potential Therapeutic Implications
Joint Authors
Constantinos, Pantos
Mourouzis, Iordanis
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Thyroid hormone (TH) is critical for adapting living organisms to environmental stress.
Plasma circulating tri-iodothyronine (T3) levels drop in most disease states and are associated with increased oxidative stress.
In this context, T3 levels in plasma appear to be an independent determinant for the recovery of cardiac function after myocardial infarction in patients.
Thyroid hormone receptor α1 (TRα1) seems to be crucial in this response; TRα1 accumulates to cell nucleus upon activation of stress induced growth kinase signaling.
Furthermore, overexpression of nuclear TRα1 in cardiomyocytes can result in pathological or physiological growth (dual action) in absence or presence of its ligand, respectively.
Accordingly, inactivation of TRα1 receptor prevents reactive hypertrophy after myocardial infarction and results in heart failure with increased phospholamban (PLB) expression and marked activation of p38MAPK.
In line with this evidence, TH is shown to limit ischemia/reperfusion injury and convert pathologic to physiologic growth after myocardial infarction via TRα1 receptor.
TRα1 receptor may prove to be a novel pharmacological target for cardiac repair/regeneration therapies.
American Psychological Association (APA)
Constantinos, Pantos& Mourouzis, Iordanis. 2014. The Emerging Role of TR α 1 in Cardiac Repair: Potential Therapeutic Implications. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047045
Modern Language Association (MLA)
Constantinos, Pantos& Mourouzis, Iordanis. The Emerging Role of TR α 1 in Cardiac Repair: Potential Therapeutic Implications. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047045
American Medical Association (AMA)
Constantinos, Pantos& Mourouzis, Iordanis. The Emerging Role of TR α 1 in Cardiac Repair: Potential Therapeutic Implications. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047045
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047045