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Lipoxygenase Pathway Mediates Increases of Airway Resistance and Lung Inflation Induced by Exposure to Nanotitanium Dioxide in Rats
Joint Authors
Lee, Jyu-Feng
Tung, Shu-Ping
Wang, David
Yeh, Diana Yuwung
Fong, Yao
Young, Yu-Chung
Leu, Fur-Jiang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nanotitanium dioxide particle (nTiO2) inhalation has been reported to induce lung parenchymal injury.
After inhalation of nTiO2, we monitored changes in 5-lipoxygenase, endothelial nitric oxide synthase (eNOS), and inducible nitric oxide synthase (iNOS) mRNA in rat lung tissue.
Lung function parameters include specific airway resistance (SRaw), peak expiratory flow rate (PEF), functional residual capacity (FRC), and lung compliance (Cchord); blood white blood cell count (WBC), nitric oxide (NO), hydrogen peroxide, and lactic dehydrogenase (LDH); and lung lavage leukotriene C4, interleukin 6 (IL6), tumor necrotic factor α (TNFα), hydroxyl radicals, and NO.
Leukotriene receptor antagonist MK571 and 5-lipoxygenase inhibitor MK886 were used for pharmacologic intervention.
Compared to control, nTiO2 exposure induced near 5-fold increase in 5-lipoxygenase mRNA expression in lung tissue.
iNOS mRNA increased while eNOS mRNA decreased.
Lavage leukotriene C4; IL6; TNFα; NO; hydroxyl radicals; and blood WBC, NO, hydrogen peroxide, and LDH levels rose.
Obstructive ventilatory insufficiency was observed.
MK571 and MK886 both attenuated the systemic inflammation and lung function changes.
We conclude that inhaled nTiO2 induces systemic inflammation, cytokine release, and oxidative and nitrosative stress in the lung.
The lipoxygenase pathway products, mediated by oxygen radicals and WBC, play a critical role in the obstructive ventilatory insufficiency induced by nTiO2.
American Psychological Association (APA)
Lee, Jyu-Feng& Tung, Shu-Ping& Wang, David& Yeh, Diana Yuwung& Fong, Yao& Young, Yu-Chung…[et al.]. 2014. Lipoxygenase Pathway Mediates Increases of Airway Resistance and Lung Inflation Induced by Exposure to Nanotitanium Dioxide in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047046
Modern Language Association (MLA)
Lee, Jyu-Feng…[et al.]. Lipoxygenase Pathway Mediates Increases of Airway Resistance and Lung Inflation Induced by Exposure to Nanotitanium Dioxide in Rats. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047046
American Medical Association (AMA)
Lee, Jyu-Feng& Tung, Shu-Ping& Wang, David& Yeh, Diana Yuwung& Fong, Yao& Young, Yu-Chung…[et al.]. Lipoxygenase Pathway Mediates Increases of Airway Resistance and Lung Inflation Induced by Exposure to Nanotitanium Dioxide in Rats. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047046