Oxidative Stress and Metabolic Syndrome: Cause or Consequence of Alzheimer's Disease?
Joint Authors
Franco-Bocanegra, Diana
Toral Rios, Danira
Campos-Peña, Victoria
Luque-Contreras, Diana
Carvajal, Karla
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a major neurodegenerative disease affecting the elderly.
Clinically, it is characterized by a progressive loss of memory and cognitive function.
Neuropathologically, it is characterized by the presence of extracellular β -amyloid (A β ) deposited as neuritic plaques (NP) and neurofibrillary tangles (NFT) made of abnormal and hyperphosphorylated tau protein.
These lesions are capable of generating the neuronal damage that leads to cell death and cognitive failure through the generation of reactive oxygen species (ROS).
Evidence indicates the critical role of A β metabolism in prompting the oxidative stress observed in AD patients.
However, it has also been proposed that oxidative damage precedes the onset of clinical and pathological AD symptoms, including amyloid- β deposition, neurofibrillary tangle formation, vascular malfunction, metabolic syndrome, and cognitive decline.
This paper provides a brief description of the three main proteins associated with the development of the disease (A β , tau, and ApoE) and describes their role in the generation of oxidative stress.
Finally, we describe the mitochondrial alterations that are generated by A β and examine the relationship of vascular damage which is a potential prognostic tool of metabolic syndrome.
In addition, new therapeutic approaches targeting ROS sources and metabolic support were reported.
American Psychological Association (APA)
Luque-Contreras, Diana& Carvajal, Karla& Toral Rios, Danira& Franco-Bocanegra, Diana& Campos-Peña, Victoria. 2014. Oxidative Stress and Metabolic Syndrome: Cause or Consequence of Alzheimer's Disease?. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047048
Modern Language Association (MLA)
Luque-Contreras, Diana…[et al.]. Oxidative Stress and Metabolic Syndrome: Cause or Consequence of Alzheimer's Disease?. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1047048
American Medical Association (AMA)
Luque-Contreras, Diana& Carvajal, Karla& Toral Rios, Danira& Franco-Bocanegra, Diana& Campos-Peña, Victoria. Oxidative Stress and Metabolic Syndrome: Cause or Consequence of Alzheimer's Disease?. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047048