Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies
Joint Authors
Pagano, Giovanni
Aiello Talamanca, Annarita
Castello, Giuseppe
Cordero, Mario D.
d’Ischia, Marco
Gadaleta, Maria Nicola
Pallardó, Federico V.
Petrović, Sandra
Tiano, Luca
Zatterale, Adriana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-04
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
Beyond the disorders recognized as mitochondrial diseases, abnormalities in function and/or ultrastructure of mitochondria have been reported in several unrelated pathologies.
These encompass ageing, malformations, and a number of genetic or acquired diseases, as diabetes and cardiologic, haematologic, organ-specific (e.g., eye or liver), neurologic and psychiatric, autoimmune, and dermatologic disorders.
The mechanistic grounds for mitochondrial dysfunction (MDF) along with the occurrence of oxidative stress (OS) have been investigated within the pathogenesis of individual disorders or in groups of interrelated disorders.
We attempt to review broad-ranging pathologies that involve mitochondrial-specific deficiencies or rely on cytosol-derived prooxidant states or on autoimmune-induced mitochondrial damage.
The established knowledge in these subjects warrants studies aimed at elucidating several open questions that are highlighted in the present review.
The relevance of OS and MDF in different pathologies may establish the grounds for chemoprevention trials aimed at compensating OS/MDF by means of antioxidants and mitochondrial nutrients.
American Psychological Association (APA)
Pagano, Giovanni& Aiello Talamanca, Annarita& Castello, Giuseppe& Cordero, Mario D.& d’Ischia, Marco& Gadaleta, Maria Nicola…[et al.]. 2014. Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-27.
https://search.emarefa.net/detail/BIM-1047052
Modern Language Association (MLA)
Pagano, Giovanni…[et al.]. Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-27.
https://search.emarefa.net/detail/BIM-1047052
American Medical Association (AMA)
Pagano, Giovanni& Aiello Talamanca, Annarita& Castello, Giuseppe& Cordero, Mario D.& d’Ischia, Marco& Gadaleta, Maria Nicola…[et al.]. Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-27.
https://search.emarefa.net/detail/BIM-1047052
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047052