Multimarker Screening of Oxidative Stress in Aging
Joint Authors
Syslová, Kamila
Böhmová, Adéla
Mikoška, Miloš
Kuzma, Marek
Pelclová, Daniela
Kačer, Petr
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Aging is a complex process of organism decline in physiological functions.
There is no clear theory explaining this phenomenon, but the most accepted one is the oxidative stress theory of aging.
Biomarkers of oxidative stress, substances, which are formed during oxidative damage of phospholipids, proteins, and nucleic acids, are present in body fluids of diseased people as well as the healthy ones (in a physiological concentration).
8-iso prostaglandin F2α is the most prominent biomarker of phospholipid oxidative damage, o-tyrosine, 3-chlorotyrosine, and 3-nitrotyrosine are biomarkers of protein oxidative damage, and 8-hydroxy-2′-deoxyguanosine and 8-hydroxyguanosine are biomarkers of oxidative damage of nucleic acids.
It is thought that the concentration of biomarkers increases as the age of people increases.
However, the concentration of biomarkers in body fluids is very low and, therefore, it is necessary to use a sensitive analytical method.
A combination of HPLC and MS was chosen to determine biomarker concentration in three groups of healthy people of a different age (twenty, forty, and sixty years) in order to find a difference among the groups.
American Psychological Association (APA)
Syslová, Kamila& Böhmová, Adéla& Mikoška, Miloš& Kuzma, Marek& Pelclová, Daniela& Kačer, Petr. 2014. Multimarker Screening of Oxidative Stress in Aging. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047054
Modern Language Association (MLA)
Syslová, Kamila…[et al.]. Multimarker Screening of Oxidative Stress in Aging. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1047054
American Medical Association (AMA)
Syslová, Kamila& Böhmová, Adéla& Mikoška, Miloš& Kuzma, Marek& Pelclová, Daniela& Kačer, Petr. Multimarker Screening of Oxidative Stress in Aging. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047054