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Effects of Treating Old Rats with an Aqueous Agaricus blazei Extract on Oxidative and Functional Parameters of the Brain Tissue and Brain Mitochondria
Joint Authors
Bracht, Adelar
Sá-Nakanishi, Anacharis Babeto de
Soares, Andréia A.
de Oliveira, Andrea L.
Fernando Comar, Jurandir
Peralta, Rosane M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Dysfunction of the mitochondrial respiratory chain and increased oxidative stress is a striking phenomenon in the brain of aged individuals.
For this reason there has been a constant search for drugs and natural products able to prevent or at least to mitigate these problems.
In the present study the effects of an aqueous extract of Agaricus blazei, a medicinal mushroom, on the oxidative state and on the functionality of mitochondria from the brain of old rats (21 months) were conducted.
The extract was administered intragastrically during 21 days at doses of 200 mg/kg.
The administration of the A.
blazei extract was protective to the brain of old rats against oxidative stress by decreasing the lipid peroxidation levels and the reactive oxygen species content and by increasing the nonenzymic and enzymic antioxidant capacities.
Administration of the A.
blazei extract also increased the activity of several mitochondrial respiratory enzymes and, depending on the substrate, the mitochondrial coupled respiration.
American Psychological Association (APA)
Sá-Nakanishi, Anacharis Babeto de& Soares, Andréia A.& de Oliveira, Andrea L.& Fernando Comar, Jurandir& Peralta, Rosane M.& Bracht, Adelar. 2014. Effects of Treating Old Rats with an Aqueous Agaricus blazei Extract on Oxidative and Functional Parameters of the Brain Tissue and Brain Mitochondria. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047055
Modern Language Association (MLA)
Sá-Nakanishi, Anacharis Babeto de…[et al.]. Effects of Treating Old Rats with an Aqueous Agaricus blazei Extract on Oxidative and Functional Parameters of the Brain Tissue and Brain Mitochondria. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1047055
American Medical Association (AMA)
Sá-Nakanishi, Anacharis Babeto de& Soares, Andréia A.& de Oliveira, Andrea L.& Fernando Comar, Jurandir& Peralta, Rosane M.& Bracht, Adelar. Effects of Treating Old Rats with an Aqueous Agaricus blazei Extract on Oxidative and Functional Parameters of the Brain Tissue and Brain Mitochondria. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047055
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047055