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Oxidative Stresses and Mitochondrial Dysfunction in Age-Related Hearing Loss
Joint Authors
Yamasoba, Tatsuya
Fujimoto, Chisato
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Age-related hearing loss (ARHL), the progressive loss of hearing associated with aging, is the most common sensory disorder in the elderly population.
The pathology of ARHL includes the hair cells of the organ of Corti, stria vascularis, and afferent spiral ganglion neurons as well as the central auditory pathways.
Many studies have suggested that the accumulation of mitochondrial DNA damage, the production of reactive oxygen species, and decreased antioxidant function are associated with subsequent cochlear senescence in response to aging stress.
Mitochondria play a crucial role in the induction of intrinsic apoptosis in cochlear cells.
ARHL can be prevented in laboratory animals by certain interventions, such as caloric restriction and supplementation with antioxidants.
In this review, we will focus on previous research concerning the role of the oxidative stress and mitochondrial dysfunction in the pathology of ARHL in both animal models and humans and introduce concepts that have recently emerged regarding the mechanisms of the development of ARHL.
American Psychological Association (APA)
Fujimoto, Chisato& Yamasoba, Tatsuya. 2014. Oxidative Stresses and Mitochondrial Dysfunction in Age-Related Hearing Loss. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047062
Modern Language Association (MLA)
Fujimoto, Chisato& Yamasoba, Tatsuya. Oxidative Stresses and Mitochondrial Dysfunction in Age-Related Hearing Loss. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1047062
American Medical Association (AMA)
Fujimoto, Chisato& Yamasoba, Tatsuya. Oxidative Stresses and Mitochondrial Dysfunction in Age-Related Hearing Loss. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047062