Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence
Joint Authors
Silva-Adaya, Daniela
Gonsebatt, María E.
Guevara, Jorge
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The reactive oxygen species produced continuously during oxidative metabolism are generated at very high rates in the brain.
Therefore, defending against oxidative stress is an essential task within the brain.
An important cellular system against oxidative stress is the thioredoxin system (TS).
TS is composed of thioredoxin, thioredoxin reductase, and NADPH.
This review focuses on the evidence gathered in recent investigations into the central nervous system, specifically the different brain regions in which the TS is expressed.
Furthermore, we address the conditions that modulate the thioredoxin system in both, animal models and the postmortem brains of human patients associated with the most common neurodegenerative disorders, in which the thioredoxin system could play an important part.
American Psychological Association (APA)
Silva-Adaya, Daniela& Gonsebatt, María E.& Guevara, Jorge. 2014. Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047064
Modern Language Association (MLA)
Silva-Adaya, Daniela…[et al.]. Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1047064
American Medical Association (AMA)
Silva-Adaya, Daniela& Gonsebatt, María E.& Guevara, Jorge. Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047064