Effect of the Antihypertensive Drug Enalapril on Oxidative Stress Markers and Antioxidant Enzymes in Kidney of Spontaneously Hypertensive Rat
Joint Authors
Nik Yusoff, Nik Syamimi
Chandran, G.
Swamy, M.
Samarendra, Mutum S.
Sirajudeen, Kuttulebbai N. S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Oxidative stress has been suggested to play a role in hypertension and hypertension induced organ damage.
This study examined the effect of enalapril, an antihypertensive drug, on oxidative stress markers and antioxidant enzymes in kidney of spontaneously hypertensive rat (SHR) and Nω -nitro-L-arginine methyl ester (L-NAME) administered SHR.
Male rats were divided into four groups (SHR, SHR+enalapril, SHR+L-NAME, and SHR+enalapril+L-NAME).
Enalapril (30 mg kg−1 day−1) was administered from week 4 to week 28 and L-NAME (25 mg kg−1 day−1) was administered from week 16 to week 28 in drinking water.
Systolic blood pressure (SBP) was measured during the experimental period.
At the end of experimental periods, rats were sacrificed; urine, blood, and kidneys were collected for the assessment of creatinine clearance, total protein, total antioxidant status (TAS), thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and catalase (CAT), as well as histopathological examination.
Enalapril treatment significantly enhanced the renal TAS level ( P < 0.001 ) and SOD activity ( P < 0.001 ), reduced the TBARS levels ( P < 0.001 ), and also prevented the renal dysfunction and histopathological changes.
The results indicate that, besides its hypotensive and renoprotective effects, enalapril treatment also diminishes oxidative stress in the kidneys of both the SHR and SHR+L-NAME groups.
American Psychological Association (APA)
Chandran, G.& Sirajudeen, Kuttulebbai N. S.& Nik Yusoff, Nik Syamimi& Swamy, M.& Samarendra, Mutum S.. 2014. Effect of the Antihypertensive Drug Enalapril on Oxidative Stress Markers and Antioxidant Enzymes in Kidney of Spontaneously Hypertensive Rat. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047067
Modern Language Association (MLA)
Chandran, G.…[et al.]. Effect of the Antihypertensive Drug Enalapril on Oxidative Stress Markers and Antioxidant Enzymes in Kidney of Spontaneously Hypertensive Rat. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047067
American Medical Association (AMA)
Chandran, G.& Sirajudeen, Kuttulebbai N. S.& Nik Yusoff, Nik Syamimi& Swamy, M.& Samarendra, Mutum S.. Effect of the Antihypertensive Drug Enalapril on Oxidative Stress Markers and Antioxidant Enzymes in Kidney of Spontaneously Hypertensive Rat. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047067