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Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways
Joint Authors
Chen, Xiaoqian
Liu, Qian Rong
Liu, Ju Mei
Chen, Yong
Xie, Xiao Qiang
Xiong, Xin Xin
Qiu, Xin Yao
Pan, Feng
Liu, Di
Yu, Shang Bin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Piperlongumine (PL) is recently found to kill cancer cells selectively and effectively via targeting reactive oxygen species (ROS) responses.
To further explore the therapeutic effects of PL in cancers, we investigated the role and mechanisms of PL in cancer cell migration.
PL effectively inhibited the migration of human glioma (LN229 or U87 MG) cells but not normal astrocytes in the scratch-wound culture model.
PL did not alter EdU+-cells and cdc2, cdc25c, or cyclin D1 expression in our model.
PL increased ROS (measured by DCFH-DA), reduced glutathione, activated p38 and JNK, increased IκBα, and suppressed NFκB in LN229 cells after scratching.
All the biological effects of PL in scratched LN229 cells were completely abolished by the antioxidant N-acetyl-L-cysteine (NAC).
Pharmacological administration of specific p38 (SB203580) or JNK (SP600125) inhibitors significantly reduced the inhibitory effects of PL on LN229 cell migration and NFκB activity in scratch-wound and/or transwell models.
PL prevented the deformation of migrated LN229 cells while NAC, SB203580, or SP600125 reversed PL-induced morphological changes of migrated cells.
These results suggest potential therapeutic effects of PL in the treatment and prevention of highly malignant tumors such as glioblastoma multiforme (GBM) in the brain by suppressing tumor invasion and metastasis.
American Psychological Association (APA)
Liu, Qian Rong& Liu, Ju Mei& Chen, Yong& Xie, Xiao Qiang& Xiong, Xin Xin& Qiu, Xin Yao…[et al.]. 2014. Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1047077
Modern Language Association (MLA)
Liu, Qian Rong…[et al.]. Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1047077
American Medical Association (AMA)
Liu, Qian Rong& Liu, Ju Mei& Chen, Yong& Xie, Xiao Qiang& Xiong, Xin Xin& Qiu, Xin Yao…[et al.]. Piperlongumine Inhibits Migration of Glioblastoma Cells via Activation of ROS-Dependent p38 and JNK Signaling Pathways. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1047077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047077