Antiapoptotic Actions of Methyl Gallate on Neonatal Rat Cardiac Myocytes Exposed to H 2O 2
Joint Authors
Khurana, Sandhya
Hollingsworth, Amanda
Piche, Matthew
Venkataraman, Krishnan
Kumar, Aseem
Ross, Gregory M.
Tai, T. C.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Reactive oxygen species trigger cardiomyocyte cell death via increased oxidative stress and have been implicated in the pathogenesis of cardiovascular diseases.
The prevention of cardiomyocyte apoptosis is a putative therapeutic target in cardioprotection.
Polyphenol intake has been associated with reduced incidences of cardiovascular disease and better overall health.
Polyphenols like epigallocatechin gallate (EGCG) can reduce apoptosis of cardiomyocytes, resulting in better health outcomes in animal models of cardiac disorders.
Here, we analyzed whether the antioxidant N-acetyl cysteine (NAC) or polyphenols EGCG, gallic acid (GA) or methyl gallate (MG) can protect cardiomyocytes from cobalt or H2O2-induced stress.
We demonstrate that MG can uphold viability of neonatal rat cardiomyocytes exposed to H2O2 by diminishing intracellular ROS, maintaining mitochondrial membrane potential, augmenting endogenous glutathione, and reducing apoptosis as evidenced by impaired Annexin V/PI staining, prevention of DNA fragmentation, and cleaved caspase-9 accumulation.
These findings suggest a therapeutic value for MG in cardioprotection.
American Psychological Association (APA)
Khurana, Sandhya& Hollingsworth, Amanda& Piche, Matthew& Venkataraman, Krishnan& Kumar, Aseem& Ross, Gregory M.…[et al.]. 2014. Antiapoptotic Actions of Methyl Gallate on Neonatal Rat Cardiac Myocytes Exposed to H 2O 2. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047079
Modern Language Association (MLA)
Khurana, Sandhya…[et al.]. Antiapoptotic Actions of Methyl Gallate on Neonatal Rat Cardiac Myocytes Exposed to H 2O 2. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047079
American Medical Association (AMA)
Khurana, Sandhya& Hollingsworth, Amanda& Piche, Matthew& Venkataraman, Krishnan& Kumar, Aseem& Ross, Gregory M.…[et al.]. Antiapoptotic Actions of Methyl Gallate on Neonatal Rat Cardiac Myocytes Exposed to H 2O 2. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047079