Human Serum Albumin Cys34 Oxidative Modifications following Infiltration in the Carotid Atherosclerotic Plaque
Joint Authors
Zinellu, Angelo
Nieddu, Gabriele
Piredda, Franco
Formato, Marilena
Carru, Ciriaco
Spirito, Rita
De Muro, Pierina
Guarino, Anna
Lepedda, Antonio Junior
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To evaluate if the prooxidant environment present in atherosclerotic plaque may oxidatively modify filtered albumin.
Methods.
Fluorescein-5-maleimide labelled plasma samples and plaque extracts from 27 patients who had undergone carotid endarterectomy were analysed through nonreducing SDS-PAGE for albumin-Cys34 oxidation.
Furthermore, degree and pattern of S-thiolation in both circulating and plaque-filtered albumin were assayed.
Results.
Albumin filtered in the atherosclerotic plaque showed higher levels of Cys34 oxidative modifications than the corresponding circulating form as well as different patterns of S-thiolation.
Conclusions.
Data indicate that the circulating albumin, once filtered in plaque, undergoes Cys34 oxidative modifications and demonstrate for the first time that albumin is a homocysteine and cysteinylglycine vehicle inside the plaque environment.
American Psychological Association (APA)
Lepedda, Antonio Junior& Zinellu, Angelo& Nieddu, Gabriele& De Muro, Pierina& Carru, Ciriaco& Spirito, Rita…[et al.]. 2014. Human Serum Albumin Cys34 Oxidative Modifications following Infiltration in the Carotid Atherosclerotic Plaque. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047087
Modern Language Association (MLA)
Lepedda, Antonio Junior…[et al.]. Human Serum Albumin Cys34 Oxidative Modifications following Infiltration in the Carotid Atherosclerotic Plaque. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1047087
American Medical Association (AMA)
Lepedda, Antonio Junior& Zinellu, Angelo& Nieddu, Gabriele& De Muro, Pierina& Carru, Ciriaco& Spirito, Rita…[et al.]. Human Serum Albumin Cys34 Oxidative Modifications following Infiltration in the Carotid Atherosclerotic Plaque. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047087