Nitric Oxide Synthetic Pathway in Patients with Microvascular Angina and Its Relations with Oxidative Stress
Joint Authors
Porro, Benedetta
Eligini, Sonia
Veglia, Fabrizio
Lualdi, Alessandro
Squellerio, Isabella
Fiorelli, Susanna
Giovannardi, Marta
Chiorino, Elisa
Dalla Cia, Alessia
Crisci, Mauro
Werba, José Pablo
Tremoli, Elena
Cavalca, Viviana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A decreased nitric oxide (NO) bioavailability and an increased oxidative stress play a pivotal role in different cardiovascular pathologies.
As red blood cells (RBCs) participate in NO formation in the bloodstream, the aim of this study was to outline the metabolic profile of L-arginine (Arg)/NO pathway and of oxidative stress status in RBCs and in plasma of patients with microvascular angina (MVA), investigating similarities and differences with respect to coronary artery disease (CAD) patients or healthy controls (Ctrl).
Analytes involved in Arg/NO pathway and the ratio of oxidized and reduced forms of glutathione were measured by LC-MS/MS.
The arginase and the NO synthase (NOS) expression were evaluated by immunofluorescence staining.
RBCs from MVA patients show increased levels of NO synthesis inhibitors, parallel to that found in plasma, and a reduction of NO synthase expression.
When summary scores were computed, both patient groups were associated with a positive oxidative score and a negative NO score, with the CAD group located in a more extreme position with respect to Ctrl.
This finding points out to an impairment of the capacity of RBCs to produce NO in a pathological condition characterized mostly by alterations at the microvascular bed with no significant coronary stenosis.
American Psychological Association (APA)
Porro, Benedetta& Eligini, Sonia& Veglia, Fabrizio& Lualdi, Alessandro& Squellerio, Isabella& Fiorelli, Susanna…[et al.]. 2014. Nitric Oxide Synthetic Pathway in Patients with Microvascular Angina and Its Relations with Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047099
Modern Language Association (MLA)
Porro, Benedetta…[et al.]. Nitric Oxide Synthetic Pathway in Patients with Microvascular Angina and Its Relations with Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047099
American Medical Association (AMA)
Porro, Benedetta& Eligini, Sonia& Veglia, Fabrizio& Lualdi, Alessandro& Squellerio, Isabella& Fiorelli, Susanna…[et al.]. Nitric Oxide Synthetic Pathway in Patients with Microvascular Angina and Its Relations with Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047099