Curcumin Inhibits Mitochondrial Injury and Apoptosis from the Early Stage in EAE Mice
Joint Authors
Feng, Jinzhou
Tao, Tao
Yan, Weiping
Chen, Cindy Si
Qin, Xinyue
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The exact pathophysiological change concerning mitochondrial injury and oligodendrocyte apoptosis in MS and EAE model is still unknown.
Whether curcumin is able to inhibit mitochondrial injury and suppress the apoptosis in the early stages of MS/EAE is still unclear.
We first explored mitochondrial injury and apoptosis at different time points p.i.
in C57 BL/6 EAE mice.
We then explored the effects of curcumin on mitochondria and apoptosis.
Results showed that mitochondrial injury can be observed 3 days p.i.
Apoptosis in the spinal cord occurred 3 days p.i.
and the apoptotic cells were shown to be oligodendrocytes and neuronal cells.
Curcumin significantly reduced the number of apoptotic cells and inhibited the upregulation of cyt-c, caspase-9, and caspase-3 at 7 days p.i.
in the EAE mice.
These observations demonstrate that mitochondrial injury and oligodendrocyte/neuronal apoptosis occur in the early stages of EAE.
Curcumin can inhibit apoptosis in EAE mice which maybe act through protection of mitochondrial injury and inhibition of the intrinsic apoptotic pathway.
American Psychological Association (APA)
Feng, Jinzhou& Tao, Tao& Yan, Weiping& Chen, Cindy Si& Qin, Xinyue. 2014. Curcumin Inhibits Mitochondrial Injury and Apoptosis from the Early Stage in EAE Mice. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047101
Modern Language Association (MLA)
Feng, Jinzhou…[et al.]. Curcumin Inhibits Mitochondrial Injury and Apoptosis from the Early Stage in EAE Mice. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047101
American Medical Association (AMA)
Feng, Jinzhou& Tao, Tao& Yan, Weiping& Chen, Cindy Si& Qin, Xinyue. Curcumin Inhibits Mitochondrial Injury and Apoptosis from the Early Stage in EAE Mice. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047101