Approach to Reduction of Blood Atherogenicity
Joint Authors
Orekhov, Alexander N.
Sobenin, Igor A.
Melnichenko, Alexandra A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We have earlier found that blood sera of patients with coronary heart disease (CHD) increase lipid levels in cells cultured from subendothelial intima of human aorta.
We have also revealed that the ability of blood sera to raise intracellular cholesterol; that is, their atherogenicity is caused by at least modified low density lipoprotein (LDL) circulating in the blood of patients and autoantibodies to modified LDL.
In the present work we have demonstrated significant impact of nonlipid factor(s) to blood atherogenicity.
We have developed an approach to removal of nonlipid atherogenicity factor(s) from blood serum based on the use of immobilized LDL.
This approach was used for extracorporeal perfusion of patient’s blood through the column with immobilized LDL.
Pilot clinical study confirmed the efficacy of this approach for prevention of coronary atherosclerosis progression.
American Psychological Association (APA)
Orekhov, Alexander N.& Melnichenko, Alexandra A.& Sobenin, Igor A.. 2014. Approach to Reduction of Blood Atherogenicity. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047105
Modern Language Association (MLA)
Orekhov, Alexander N.…[et al.]. Approach to Reduction of Blood Atherogenicity. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047105
American Medical Association (AMA)
Orekhov, Alexander N.& Melnichenko, Alexandra A.& Sobenin, Igor A.. Approach to Reduction of Blood Atherogenicity. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047105
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047105