Oxidative Stress: Implications for the Development of Diabetic Retinopathy and Antioxidant Therapeutic Perspectives
Joint Authors
Wu, Ying
Tang, Luosheng
Chen, Baihua
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In recent decades, localized tissue oxidative stress has been implicated as a key component in the development of diabetic retinopathy (DR).
Increasing evidence shows that oxidative stress caused by diabetes-induced metabolic abnormalities is the most common mechanism associated with the pathogenesis of DR for both type 1 and type 2 diabetes.
Increase in intracellular reactive oxygen species (ROS) concentrations results in the activation of several mechanisms involved in the pathogenesis of DR.
In particular, damage or dysfunction caused by oxidative stress still persists even after glycemia has been normalized.
Despite considerable evidence showing the beneficial effects of antioxidants in preventing the development of retinopathy, results from large-scale clinical trials on classic antioxidants are somewhat ambiguous.
Scavenging reactive radicals may not be the most ideal antioxidant strategy in DR.
Advances in understanding the function of ROS in the development of DR can lead to the development of new therapeutic strategies based on the mechanisms of ROS generation and scavenging.
Increasing amounts of data have demonstrated the promising prospect of antioxidant therapy and its beneficial effects in vision protection.
Therefore, new strategies that utilize antioxidants as additive therapy should be implemented in the treatment of DR.
American Psychological Association (APA)
Wu, Ying& Tang, Luosheng& Chen, Baihua. 2014. Oxidative Stress: Implications for the Development of Diabetic Retinopathy and Antioxidant Therapeutic Perspectives. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1047109
Modern Language Association (MLA)
Wu, Ying…[et al.]. Oxidative Stress: Implications for the Development of Diabetic Retinopathy and Antioxidant Therapeutic Perspectives. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1047109
American Medical Association (AMA)
Wu, Ying& Tang, Luosheng& Chen, Baihua. Oxidative Stress: Implications for the Development of Diabetic Retinopathy and Antioxidant Therapeutic Perspectives. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1047109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047109