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Analysis of Oxidative Stress Enzymes and Structural and Functional Proteins on Human Aortic Tissue from Different Aortopathies
Joint Authors
Soto, María Elena
Guarner Lans, Verónica
Pérez-Torres, Israel
Soria-Castro, Elizabeth
Muruato Ontiveros, Eleazar
Iván Hernández Mejía, Benjamín
Jorge Martínez Hernandez, Humberto
Barragán García, Rodolfo
Herrera, Valentín
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The role of oxidative stress in different aortopathies is evaluated.
Thirty-two tissue samples from 18 men and 14 women were divided into: 4 control (C) subjects, 11 patients with systemic arterial hypertension (SAH), 4 with variants of Marfan’s syndrome (MV), 9 with Marfan’s syndrome (M), 2 with Turner’s syndrome, and 2 with Takayasu’s arteritis (TA).
Aorta fragments were homogenized.
Lipoperoxidation (LPO), copper-zinc and manganese superoxide dismutase (Mn and Cu-Zn-SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), endothelial nitric oxide synthase (eNOS), nitrates and nitrites ( NO 3 − / NO 2 − ), and type IV collagen, and laminin were evaluated.
There was an increase in Mn- and Cu-Zn-SOD activity in SAH, MV, M, and Turner’s syndrome.
There was also an increase in CAT activity in M and Turner’ syndrome.
GPx and GST activity decreased and LPO increased in all groups.
eNOS was decreased in SAH, MV, and M and NO 3 − / NO 2 − were increased in SAH and TA.
Type IV collagen was decreased in Turner’s syndrome and TA.
Laminin γ -1 was decreased in MV and increased in M.
In conclusion, similarities and differences in oxidative stress in the different aortopathies studied including pathologies with aneurysms were found with alterations in SOD, CAT, GPx, GST, and eNOS activity that modify subendothelial basement membrane proteins.
American Psychological Association (APA)
Soto, María Elena& Soria-Castro, Elizabeth& Guarner Lans, Verónica& Muruato Ontiveros, Eleazar& Iván Hernández Mejía, Benjamín& Jorge Martínez Hernandez, Humberto…[et al.]. 2014. Analysis of Oxidative Stress Enzymes and Structural and Functional Proteins on Human Aortic Tissue from Different Aortopathies. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047114
Modern Language Association (MLA)
Soto, María Elena…[et al.]. Analysis of Oxidative Stress Enzymes and Structural and Functional Proteins on Human Aortic Tissue from Different Aortopathies. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1047114
American Medical Association (AMA)
Soto, María Elena& Soria-Castro, Elizabeth& Guarner Lans, Verónica& Muruato Ontiveros, Eleazar& Iván Hernández Mejía, Benjamín& Jorge Martínez Hernandez, Humberto…[et al.]. Analysis of Oxidative Stress Enzymes and Structural and Functional Proteins on Human Aortic Tissue from Different Aortopathies. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1047114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047114