Amyloid Beta: Multiple Mechanisms of Toxicity and Only Some Protective Effects?
Joint Authors
Carrillo-Mora, Paul
Luna, Rogelio
Colin-Barenque, L.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-05
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Amyloid beta (Aβ) is a peptide of 39–43 amino acids found in large amounts and forming deposits in the brain tissue of patients with Alzheimer’s disease (AD).
For this reason, it has been implicated in the pathophysiology of damage observed in this type of dementia.
However, the role of Aβ in the pathophysiology of AD is not yet precisely understood.
Aβ has been experimentally shown to have a wide range of toxic mechanisms in vivo and in vitro, such as excitotoxicity, mitochondrial alterations, synaptic dysfunction, altered calcium homeostasis, oxidative stress, and so forth.
In contrast, Aβ has also shown some interesting neuroprotective and physiological properties under certain experimental conditions, suggesting that both physiological and pathological roles of Aβ may depend on several factors.
In this paper, we reviewed both toxic and protective mechanisms of Aβ to further explore what their potential roles could be in the pathophysiology of AD.
The complete understanding of such apparently opposed effects will also be an important guide for the therapeutic efforts coming in the future.
American Psychological Association (APA)
Carrillo-Mora, Paul& Luna, Rogelio& Colin-Barenque, L.. 2014. Amyloid Beta: Multiple Mechanisms of Toxicity and Only Some Protective Effects?. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1047139
Modern Language Association (MLA)
Carrillo-Mora, Paul…[et al.]. Amyloid Beta: Multiple Mechanisms of Toxicity and Only Some Protective Effects?. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1047139
American Medical Association (AMA)
Carrillo-Mora, Paul& Luna, Rogelio& Colin-Barenque, L.. Amyloid Beta: Multiple Mechanisms of Toxicity and Only Some Protective Effects?. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1047139
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047139