Oxidative Stress Activates the Transcription Factors FoxO 1a and FoxO 3a in the Hippocampus of Rats Exposed to Low Doses of Ozone
Joint Authors
Rodríguez-Martínez, Erika
Gómez-Crisóstomo, Nancy P.
Rivas-Arancibia, Selva
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The exposure to low doses of ozone induces an oxidative stress state, which is involved in neurodegenerative diseases.
Forkhead box O (FoxO) family of transcription factors are activated by oxidative signals and regulate cell proliferation and resistance to oxidative stress.
Our aim was to study the effect of chronic exposure to ozone on the activation of FoxO 1a and FoxO 3a in the hippocampus of rats.
Male Wistar rats were divided into six groups and exposed to 0.25 ppm of ozone for 0, 7, 15, 30, 60, and 90 days.
After treatment, the groups were processed for western blotting and immunohistochemistry against FoxO 3a, Mn SOD, cyclin D2, FoxO 1a, and active caspase 3.
We found that exposure to ozone increased the activation of FoxO 3a at 30 and 60 days and expression of Mn SOD at all treatment times.
Additionally, increases in cyclin D2 from 7 to 90 days; FoxO 1a at 15, 30, and 60 days; and activate caspase 3 from 30 to 60 days of exposure were noted.
The results indicate that ozone alters regulatory pathways related to both the antioxidant system and the cell cycle, inducing neuronal reentry into the cell cycle and apoptotic death.
American Psychological Association (APA)
Gómez-Crisóstomo, Nancy P.& Rodríguez-Martínez, Erika& Rivas-Arancibia, Selva. 2014. Oxidative Stress Activates the Transcription Factors FoxO 1a and FoxO 3a in the Hippocampus of Rats Exposed to Low Doses of Ozone. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047141
Modern Language Association (MLA)
Gómez-Crisóstomo, Nancy P.…[et al.]. Oxidative Stress Activates the Transcription Factors FoxO 1a and FoxO 3a in the Hippocampus of Rats Exposed to Low Doses of Ozone. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047141
American Medical Association (AMA)
Gómez-Crisóstomo, Nancy P.& Rodríguez-Martínez, Erika& Rivas-Arancibia, Selva. Oxidative Stress Activates the Transcription Factors FoxO 1a and FoxO 3a in the Hippocampus of Rats Exposed to Low Doses of Ozone. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047141