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Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group of Subjects with Metabolic Syndrome
Joint Authors
Averna, Maurizio
Hopps, E.
Lo Presti, R.
Montana, M.
Canino, B.
Caimi, G.
Noto, Davide
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Our aim was to evaluate lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), nitric oxide metabolites (nitrite + nitrate) expressed as NO x , and TBARS/ NO x ratio in a group of subjects with metabolic syndrome (MS).
In this regard we enrolled 106 subjects with MS defined according to the IDF criteria, subsequently subdivided into diabetic (DMS) and nondiabetic (NDMS) and also into subjects with a low triglycerides/HDL-cholesterol (TG/HDL-C) index or with a high TG/HDL-C index.
In the entire group and in the four subgroups of MS subjects we found an increase in TBARS and NO x levels and a decrease in TBARS/ NO x ratio in comparison with normal controls.
Regarding all these parameters no statistical difference between DMS and NDMS was evident, but a significant increase in NO x was present in subjects with a high TG/HDL-C index in comparison with those with a low index.
In MS subjects we also found a negative correlation between TBARS/ NO x ratio and TG/HDL-C index.
Considering the hyperactivity of the inducible NO synthase in MS, these data confirm the altered redox and inflammatory status that characterizes the MS and suggest a link between lipid peroxidation, inflammation, and insulin resistance, evaluated as TG/HDL-C index.
American Psychological Association (APA)
Caimi, G.& Lo Presti, R.& Montana, M.& Noto, Davide& Canino, B.& Averna, Maurizio…[et al.]. 2014. Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group of Subjects with Metabolic Syndrome. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047145
Modern Language Association (MLA)
Caimi, G.…[et al.]. Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group of Subjects with Metabolic Syndrome. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047145
American Medical Association (AMA)
Caimi, G.& Lo Presti, R.& Montana, M.& Noto, Davide& Canino, B.& Averna, Maurizio…[et al.]. Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group of Subjects with Metabolic Syndrome. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047145