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Psoralea corylifolia L. Seed Extract Ameliorates Streptozotocin-Induced Diabetes in Mice by Inhibition of Oxidative Stress
Joint Authors
Lee, Eun-Kyu
Lee, Cheol Soon
Chun, Kwang-Hoon
Seo, Eunhui
Jun, Hee-Sook
Lee, Mi-Young
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Pancreatic beta-cell death is known to be the cause of deficient insulin production in diabetes mellitus.
Oxidative stress is one of the major causes of beta-cell death.
In this study, we investigated the effects of Psoralea corylifolia L.
seed (PCS) extract on beta-cell death.
Oral administration of PCS extract resulted in a significant improvement of hyperglycemia in streptozotocin-induced diabetic mice.
PCS extract treatment improved glucose tolerance and increased serum insulin levels.
To study the mechanisms involved, we investigated the effects of PCS extract on H2O2-induced apoptosis in INS-1 cells.
Treatment with PCS extract inhibited cell death.
PCS extract treatment decreased reactive oxygen species level and activated antioxidative enzymes.
Among the major components of PCS extract, psoralen and isopsoralen (coumarins), but not bakuchiol, showed preventive effects against H2O2-induced beta-cell death.
These findings indicate that PCS extract may be a potential pharmacological agent to protect against pancreatic beta-cell damage caused by oxidative stress associated with diabetes.
American Psychological Association (APA)
Seo, Eunhui& Lee, Eun-Kyu& Lee, Cheol Soon& Chun, Kwang-Hoon& Lee, Mi-Young& Jun, Hee-Sook. 2014. Psoralea corylifolia L. Seed Extract Ameliorates Streptozotocin-Induced Diabetes in Mice by Inhibition of Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047156
Modern Language Association (MLA)
Seo, Eunhui…[et al.]. Psoralea corylifolia L. Seed Extract Ameliorates Streptozotocin-Induced Diabetes in Mice by Inhibition of Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047156
American Medical Association (AMA)
Seo, Eunhui& Lee, Eun-Kyu& Lee, Cheol Soon& Chun, Kwang-Hoon& Lee, Mi-Young& Jun, Hee-Sook. Psoralea corylifolia L. Seed Extract Ameliorates Streptozotocin-Induced Diabetes in Mice by Inhibition of Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047156