Oxidative Status Imbalance in Patients with Metabolic Syndrome: Role of the MyeloperoxidaseHydrogen Peroxide Axis
Joint Authors
Rabelo, Luíza A.
Nunes-Souza, Valéria
Schettino-Silva, Glauber
Mota-Gomes, Marco Antônio
Guedes, Glaucevane da S.
Fonseca, Lucas José S. da
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The present study evaluated the cardiometabolic and redox balance profiles in patients with Metabolic Syndrome compared to apparently healthy individuals, and the participation of the myeloperoxidase/hydrogen peroxide axis in systemic lipid peroxidation.
Twenty-four patients with Metabolic Syndrome and eighteen controls underwent a full clinical assessment.
Venous blood samples were collected for general biochemical dosages, as well as for the oxidative stress analyses (superoxide dismutase, catalase, and arginase activities; and lipid peroxidation, myeloperoxidase activity, nitrite, and hydrogen peroxide concentrations in plasma).
Arterial stiffness was assessed by radial artery applanation tonometry.
Plasma lipid peroxidation, erythrocyte superoxide dismutase activity, myeloperoxidase activity, and hydrogen peroxide concentrations were shown to be increased in Metabolic Syndrome patients, without significant differences for the other enzymes, plasma nitrite concentrations, and arterial stiffness.
Linear regression analysis revealed a positive and significant correlation between lipid peroxidation and myeloperoxidase and also between this enzyme and hydrogen peroxide.
In contrast, such correlation was not observed between lipid peroxidation and hydrogen peroxide.
In summary, Metabolic Syndrome patients exhibited evident systemic redox imbalance compared to controls, with the possible participation of the myeloperoxidase/hydrogen peroxide axis as a contributor in lipid peroxidation.
American Psychological Association (APA)
Fonseca, Lucas José S. da& Nunes-Souza, Valéria& Guedes, Glaucevane da S.& Schettino-Silva, Glauber& Mota-Gomes, Marco Antônio& Rabelo, Luíza A.. 2014. Oxidative Status Imbalance in Patients with Metabolic Syndrome: Role of the MyeloperoxidaseHydrogen Peroxide Axis. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047157
Modern Language Association (MLA)
Fonseca, Lucas José S. da…[et al.]. Oxidative Status Imbalance in Patients with Metabolic Syndrome: Role of the MyeloperoxidaseHydrogen Peroxide Axis. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1047157
American Medical Association (AMA)
Fonseca, Lucas José S. da& Nunes-Souza, Valéria& Guedes, Glaucevane da S.& Schettino-Silva, Glauber& Mota-Gomes, Marco Antônio& Rabelo, Luíza A.. Oxidative Status Imbalance in Patients with Metabolic Syndrome: Role of the MyeloperoxidaseHydrogen Peroxide Axis. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047157