Piperlongumine Induces Apoptosis and Synergizes with Cisplatin or Paclitaxel in Human Ovarian Cancer Cells

Joint Authors

Xue, You-Qiu
Shi, Zhi
Gong, Li-Hua
Chen, Xiu-Xiu
Wang, Huan
Jiang, Qi-Wei
Pan, Shi-Shi
Qiu, Jian-Ge
Mei, Xiao-Long
Qin, Wu-Ming
Zheng, Fei-Yun
Yan, Xiao-Jian

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-05-08

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Biology

Abstract EN

Piperlongumine (PL), a natural alkaloid from Piper longum L., possesses the highly selective and effective anticancer property.

However, the effect of PL on ovarian cancer cells is still unknown.

In this study, we firstly demonstrate that PL selectively inhibited cell growth of human ovarian cancer cells.

Furthermore, PL notably induced cell apoptosis, G2/M phase arrest, and accumulation of the intracellular reactive oxidative species (ROS) in a dose- and time-dependent manner.

Pretreatment with antioxidant N-acety-L-cysteine could totally reverse the PL-induced ROS accumulation and cell apoptosis.

In addition, low dose of PL/cisplatin or paclitaxel combination therapies had a synergistic antigrowth effect on human ovarian cancer cells.

Collectively, our study provides new therapeutic potential of PL on human ovarian cancer.

American Psychological Association (APA)

Gong, Li-Hua& Chen, Xiu-Xiu& Wang, Huan& Jiang, Qi-Wei& Pan, Shi-Shi& Qiu, Jian-Ge…[et al.]. 2014. Piperlongumine Induces Apoptosis and Synergizes with Cisplatin or Paclitaxel in Human Ovarian Cancer Cells. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047160

Modern Language Association (MLA)

Gong, Li-Hua…[et al.]. Piperlongumine Induces Apoptosis and Synergizes with Cisplatin or Paclitaxel in Human Ovarian Cancer Cells. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047160

American Medical Association (AMA)

Gong, Li-Hua& Chen, Xiu-Xiu& Wang, Huan& Jiang, Qi-Wei& Pan, Shi-Shi& Qiu, Jian-Ge…[et al.]. Piperlongumine Induces Apoptosis and Synergizes with Cisplatin or Paclitaxel in Human Ovarian Cancer Cells. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047160

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1047160