Piperlongumine Induces Apoptosis and Synergizes with Cisplatin or Paclitaxel in Human Ovarian Cancer Cells
Joint Authors
Xue, You-Qiu
Shi, Zhi
Gong, Li-Hua
Chen, Xiu-Xiu
Wang, Huan
Jiang, Qi-Wei
Pan, Shi-Shi
Qiu, Jian-Ge
Mei, Xiao-Long
Qin, Wu-Ming
Zheng, Fei-Yun
Yan, Xiao-Jian
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Piperlongumine (PL), a natural alkaloid from Piper longum L., possesses the highly selective and effective anticancer property.
However, the effect of PL on ovarian cancer cells is still unknown.
In this study, we firstly demonstrate that PL selectively inhibited cell growth of human ovarian cancer cells.
Furthermore, PL notably induced cell apoptosis, G2/M phase arrest, and accumulation of the intracellular reactive oxidative species (ROS) in a dose- and time-dependent manner.
Pretreatment with antioxidant N-acety-L-cysteine could totally reverse the PL-induced ROS accumulation and cell apoptosis.
In addition, low dose of PL/cisplatin or paclitaxel combination therapies had a synergistic antigrowth effect on human ovarian cancer cells.
Collectively, our study provides new therapeutic potential of PL on human ovarian cancer.
American Psychological Association (APA)
Gong, Li-Hua& Chen, Xiu-Xiu& Wang, Huan& Jiang, Qi-Wei& Pan, Shi-Shi& Qiu, Jian-Ge…[et al.]. 2014. Piperlongumine Induces Apoptosis and Synergizes with Cisplatin or Paclitaxel in Human Ovarian Cancer Cells. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047160
Modern Language Association (MLA)
Gong, Li-Hua…[et al.]. Piperlongumine Induces Apoptosis and Synergizes with Cisplatin or Paclitaxel in Human Ovarian Cancer Cells. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047160
American Medical Association (AMA)
Gong, Li-Hua& Chen, Xiu-Xiu& Wang, Huan& Jiang, Qi-Wei& Pan, Shi-Shi& Qiu, Jian-Ge…[et al.]. Piperlongumine Induces Apoptosis and Synergizes with Cisplatin or Paclitaxel in Human Ovarian Cancer Cells. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047160
