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Free Radicals in Adolescent Varicocele Testis
Joint Authors
Romeo, Carmelo
Santoro, Giuseppe
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We examine the relationship between the structure and function of the testis and the oxidative and nitrosative stress, determined by an excessive production of free radicals and/or decreased availability of antioxidant defenses, which occur in the testis of adolescents affected by varicocele.
Moreover, the effects of surgical treatment on oxidative stress were provided.
We conducted a PubMed and Medline search between 1980 and 2014 using “adolescent,” “varicocele,” “free radicals,” “oxidative and nitrosative stress,” “testis,” and “seminiferous tubules” as keywords.
Cross-references were checked in each of the studies, and relevant articles were retrieved.
We conclude that increased concentration of free radicals, generated by conditions of hypoxia, hyperthermia, and hormonal dysfunction observed in adolescent affected by varicocele, can harm germ cells directly or indirectly by influencing nonspermatogenic cells and basal lamina.
With regard to few available data in current literature, further clinical trials on the pre- and postoperative ROS and RNS levels together with morphological studies of the cellular component of the testis are fundamental for complete comprehension of the role played by free radicals in the pathogenesis of adolescent varicocele and could justify its pharmacological treatment with antioxidants.
American Psychological Association (APA)
Romeo, Carmelo& Santoro, Giuseppe. 2014. Free Radicals in Adolescent Varicocele Testis. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047163
Modern Language Association (MLA)
Romeo, Carmelo& Santoro, Giuseppe. Free Radicals in Adolescent Varicocele Testis. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1047163
American Medical Association (AMA)
Romeo, Carmelo& Santoro, Giuseppe. Free Radicals in Adolescent Varicocele Testis. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1047163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047163