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Anti-Inflammatory Effect of Recreational Exercise in TNBS-Induced Colitis in Rats: Role of NOSHOMPO System
Joint Authors
Varga, Csaba
Gyöngyösi, Mariann
Nagy, István
Szalai, Zita
Szász, András
Puskás, László G.
Király, Adél
Strifler, Gerda
Baráth, Zoltán
Nagy, Lajos I.
Murlasits, Zsolt
Kupai, Krisztina
Berkó, Anikó
Pósa, Anikó
Szabó, Renáta
Pávó, Imre
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
There are opposite views in the available literature: Whether physical exercise has a protective effect or not on the onset of inflammatory bowel disease (IBD).
Therefore, we investigated the effects of recreational physical exercise before the induction of colitis.
After 6 weeks of voluntary physical activity (running wheel), male Wistar rats were treated with TNBS (10 mg).
72 hrs after trinitrobenzene sulphonic acid (TNBS) challenge we measured colonic gene (TNF-α, IL-1β, CXCL1 and IL-10) and protein (TNF-α) expressions of various inflammatory mediators and enzyme activities of heme oxygenase (HO), nitric oxide synthase (NOS), and myeloperoxidase (MPO) enzymes.
Wheel running significantly increased the activities of HO, constitutive NOS (cNOS) isoform.
Furthermore, 6 weeks of running significantly decreased TNBS-induced inflammatory markers, including extent of lesions, severity of mucosal damage, and gene expression of IL-1β, CXCL1, and MPO activity, while IL-10 gene expression and cNOS activity were increased.
iNOS activity decreased and the activity of HO enzyme increased, but not significantly, compared to the sedentary TNBS-treated group.
In conclusion, recreational physical exercise can play an anti-inflammatory role by downregulating the gene expression of proinflammatory mediators, inducing anti-inflammatory mediators, and modulating the activities of HO and NOS enzymes in a rat model of colitis.
American Psychological Association (APA)
Szalai, Zita& Szász, András& Nagy, István& Puskás, László G.& Kupai, Krisztina& Király, Adél…[et al.]. 2014. Anti-Inflammatory Effect of Recreational Exercise in TNBS-Induced Colitis in Rats: Role of NOSHOMPO System. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047166
Modern Language Association (MLA)
Szalai, Zita…[et al.]. Anti-Inflammatory Effect of Recreational Exercise in TNBS-Induced Colitis in Rats: Role of NOSHOMPO System. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1047166
American Medical Association (AMA)
Szalai, Zita& Szász, András& Nagy, István& Puskás, László G.& Kupai, Krisztina& Király, Adél…[et al.]. Anti-Inflammatory Effect of Recreational Exercise in TNBS-Induced Colitis in Rats: Role of NOSHOMPO System. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047166
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047166