Polyol Pathway Exacerbated IschemiaReperfusion-Induced Injury in Steatotic Liver
Joint Authors
Zhang, Changhe
Huang, Changjun
Tian, Yuan
Li, Xiangcheng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The polyol pathway, a bypass pathway of glucose metabolism initiated by aldose reductase (AR), has been shown to play an important role in mediating tissue ischemia/reperfusion (I/R) impairment recently.
Here, we investigated how and why this pathway might affect the fatty liver following I/R.
Methods.
Two opposite models were created: mice with high-fat-diet-induced liver steatosis were treated with aldose reductase inhibition (ARI) and subsequent I/R; and AR-overexpressing L02 hepatocytes were sequentially subjected to steatosis and hypoxia/reoxygenation.
We next investigated (a) the hepatic injuries, including liver function, histology, and hepatocytes apoptosis/necrosis; (b) the NAD(P)(H) contents, redox status, and mitochondrial function; and (c) the flux through the caspase-dependent apoptosis pathway.
Results.
AR-inhibition in vivo markedly attenuated the I/R-induced liver injuries, maintained the homeostasis of NAD(P)(H) contents and redox status, and suppressed the caspase-dependent apoptosis pathway.
Correspondingly, AR overexpression in vitro presented the opposite effects.
Conclusion.
The flux through the polyol pathway may render steatotic liver greater vulnerability to I/R.
Interventions targeting this pathway might provide a novel adjunctive approach to protect fatty liver from ischemia.
American Psychological Association (APA)
Zhang, Changhe& Huang, Changjun& Tian, Yuan& Li, Xiangcheng. 2014. Polyol Pathway Exacerbated IschemiaReperfusion-Induced Injury in Steatotic Liver. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047171
Modern Language Association (MLA)
Zhang, Changhe…[et al.]. Polyol Pathway Exacerbated IschemiaReperfusion-Induced Injury in Steatotic Liver. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047171
American Medical Association (AMA)
Zhang, Changhe& Huang, Changjun& Tian, Yuan& Li, Xiangcheng. Polyol Pathway Exacerbated IschemiaReperfusion-Induced Injury in Steatotic Liver. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047171