The Magnolia Bioactive Constituent 4-O-Methylhonokiol Protects against High-Fat Diet-Induced Obesity and Systemic Insulin Resistance in Mice

Joint Authors

Jiang, Xin
Cai, Lu
Kim, Ki-Soo
Zheng, Yang
Zhang, Zhiguo
Kim, Ki Ho
Wang, Jian
Chen, Jing
Yan, Xiaoqing
Conklin, Daniel J.
Tan, Yi
Kim, Young Heui

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-05-29

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Biology

Abstract EN

Obesity is caused by a combination of both genetic and environmental risks.

Disruption in energy balance is one of these risk factors.

In the present study, the preventive effect on high-fat diet- (HFD-) induced obesity and insulin resistance in mice by Magnolia bioactive constituent 4-O-methylhonokiol (MH) was compared with Magnolia officinalis extract BL153.

C57BL/6J mice were fed by normal diet or by HFD with gavage-administered vehicle, BL153, low-dose MH, and high-dose MH simultaneously for 24 weeks, respectively.

Either MH or BL153 slightly inhibited body-weight gain of mice by HFD feeding although the food intake had no obvious difference.

Body fat mass and the epididymal white adipose tissue weight were also mildly decreased by MH or BL153.

Moreover, MH significantly lowered HFD-induced plasma triglyceride, cholesterol levels and activity of alanine transaminase (ALT), liver weight and hepatic triglyceride level, and ameliorated hepatic steatosis.

BL153 only significantly reduced ALT and liver triglyceride level.

Concurrently, low-dose MH improved HFD-induced hyperinsulinemia and insulin resistance.

Furthermore, the infiltration of mast cells in adipose tissue was decreased in MH or in BL153 treatment.

These results suggested that Magnolia bioactive constituent MH might exhibit potential benefits for HFD-induced obesity by improvement of lipid metabolism and insulin resistance.

American Psychological Association (APA)

Zhang, Zhiguo& Chen, Jing& Jiang, Xin& Wang, Jian& Yan, Xiaoqing& Zheng, Yang…[et al.]. 2014. The Magnolia Bioactive Constituent 4-O-Methylhonokiol Protects against High-Fat Diet-Induced Obesity and Systemic Insulin Resistance in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047172

Modern Language Association (MLA)

Zhang, Zhiguo…[et al.]. The Magnolia Bioactive Constituent 4-O-Methylhonokiol Protects against High-Fat Diet-Induced Obesity and Systemic Insulin Resistance in Mice. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047172

American Medical Association (AMA)

Zhang, Zhiguo& Chen, Jing& Jiang, Xin& Wang, Jian& Yan, Xiaoqing& Zheng, Yang…[et al.]. The Magnolia Bioactive Constituent 4-O-Methylhonokiol Protects against High-Fat Diet-Induced Obesity and Systemic Insulin Resistance in Mice. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047172

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1047172