Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3KAkt and Nrf2 Signaling Pathway
Joint Authors
Qi, Hong-yi
Yu, Jie
Huang, Yong-liang
Wan, Fang
Zhang, Wenwu
Yang, Huarong
Wang, Li
Wu, Chunjie
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Panaxatriol saponins (PTS), the main components extracted from Panax notoginseng, have been shown to be efficacious in the prevention and treatment of cerebrovascular diseases in China.
NF-E2-related factor 2 (Nrf2), a transcription factor regulating antioxidant and cytoprotective responses to oxidative stress, has received particular attention as a molecular target for pharmacological intervention of ischemic diseases.
The aim of this study was to characterize the effect of PTS on the activation of Nrf2 signaling pathway and the potential role in its protective effect.
We found that PTS induced heme oxygenase-1 (HO-1) expression in PC12 cells via activating Nrf2 signaling pathway.
Phosphatidylinositol 3-kinase (PI3K)/Akt kinase was involved in the upstream of this PTS activated pathway.
Moreover, combination of the main components in PTS significantly enhanced the expression of Nrf2 mediated phase II enzymes.
Importantly, the protective effect of PTS against oxygen-glucose deprivation-reperfusion (OGD-Rep) induced cell death was significantly attenuated by PI3K inhibitor and antioxidant response element (ARE) decoy oligonucleotides, suggesting that both PI3K/Akt and Nrf2 signaling pathway are essential during this protective process.
Taken together, our results suggest that PTS may activate endogenous cytoprotective mechanism against OGD-Rep induced oxidative injury via the activation of PI3K/Akt and Nrf2 signaling pathway.
American Psychological Association (APA)
Huang, Yong-liang& Yu, Jie& Wan, Fang& Zhang, Wenwu& Yang, Huarong& Wang, Li…[et al.]. 2014. Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3KAkt and Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047174
Modern Language Association (MLA)
Huang, Yong-liang…[et al.]. Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3KAkt and Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1047174
American Medical Association (AMA)
Huang, Yong-liang& Yu, Jie& Wan, Fang& Zhang, Wenwu& Yang, Huarong& Wang, Li…[et al.]. Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3KAkt and Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047174
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047174