Cardiovascular Complications of Sleep Apnea: Role of Oxidative Stress
Joint Authors
Badran, Mohammad
Ayas, Najib
Laher, Ismail
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Obstructive sleep apnea (OSA) occurs in 2% of middle-aged women and 4% of middle-aged men with a higher prevalence among obese subjects.
This condition is considered as an independent risk factor for cerebrovascular and cardiovascular diseases.
One of the major pathophysiological characteristics of OSA is intermittent hypoxia.
Hypoxia can lead to oxidative stress and overproduction of reactive oxygen species, which can lead to endothelial dysfunction, a hallmark of atherosclerosis.
Many animal models, such as the rodent model of intermittent hypoxia, mimic obstructive sleep apnea in human patients and allow more in-depth investigation of biological and cellular mechanisms of this condition.
This review discusses the role of oxidative stress in cardiovascular disease resulting from OSA in humans and animal models.
American Psychological Association (APA)
Badran, Mohammad& Ayas, Najib& Laher, Ismail. 2014. Cardiovascular Complications of Sleep Apnea: Role of Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047175
Modern Language Association (MLA)
Badran, Mohammad…[et al.]. Cardiovascular Complications of Sleep Apnea: Role of Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047175
American Medical Association (AMA)
Badran, Mohammad& Ayas, Najib& Laher, Ismail. Cardiovascular Complications of Sleep Apnea: Role of Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047175
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047175