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Comparison of Transperineal Mapping Biopsy Results with Whole-Mount Radical Prostatectomy Pathology in Patients with Localized Prostate Cancer
Joint Authors
Katz, Darren J.
Pinochet, Rodrigo
Richards, Kyle A.
Godoy, Guilherme
Udo, Kazuma
Nogueira, Lucas
Cronin, Angel M.
Fine, Samson W.
Scardino, Peter T.
Coleman, Jonathon A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
We sought to evaluate the accuracy of transperineal mapping biopsy (TMB) by comparing it to the pathology specimen of patients who underwent radical prostatectomy (RP) for localized prostate cancer.
Methods.
From March 2007 to September 2009, 78 men at a single center underwent TMB; 17 of 78 subsequently underwent RP.
TMB cores were grouped into four quadrants and matched to data from RP whole-mount slides.
Gleason score, tumor location and volume, cross-sectional area, and maximal diameter were measured; sensitivity and specificity were assessed.
Results.
For the 17 patients who underwent RP, TMB revealed 12 (71%) had biopsy Gleason grades ≥ 3 + 4 and 13 (76%) had bilateral disease.
RP specimens showed 14 (82%) had Gleason scores ≥ 3 + 4 and 13 (76%) had bilateral disease.
Sensitivity and specificity of TMB for prostate cancer detection were 86% (95% confidence interval [CI] 72%–94%) and 83% (95% CI 62%–95%), respectively.
Four quadrants negative for cancer on TMB were positive on prostatectomy, and six positive on TMB were negative on prostatectomy.
Conclusion.
TMB is a highly invasive procedure that can accurately detect and localize prostate cancer.
These findings help establish baseline performance characteristics for TMB and its utility for organ-sparing strategies.
American Psychological Association (APA)
Katz, Darren J.& Pinochet, Rodrigo& Richards, Kyle A.& Godoy, Guilherme& Udo, Kazuma& Nogueira, Lucas…[et al.]. 2014. Comparison of Transperineal Mapping Biopsy Results with Whole-Mount Radical Prostatectomy Pathology in Patients with Localized Prostate Cancer. Prostate Cancer،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047196
Modern Language Association (MLA)
Katz, Darren J.…[et al.]. Comparison of Transperineal Mapping Biopsy Results with Whole-Mount Radical Prostatectomy Pathology in Patients with Localized Prostate Cancer. Prostate Cancer No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047196
American Medical Association (AMA)
Katz, Darren J.& Pinochet, Rodrigo& Richards, Kyle A.& Godoy, Guilherme& Udo, Kazuma& Nogueira, Lucas…[et al.]. Comparison of Transperineal Mapping Biopsy Results with Whole-Mount Radical Prostatectomy Pathology in Patients with Localized Prostate Cancer. Prostate Cancer. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047196