Independent Validation of the SEND-PD and Correlation with the MDS-UPDRS Part IA

Abstract EN

Introduction.

Neuropsychiatric symptoms in Parkinson’s disease can be assessed by the MDS-UPDRS part IA.

The Scale for Evaluation of Neuropsychiatric Disorders in Parkinson’s disease (SEND-PD) has been recently developed to assess the severity of some neuropsychiatric symptoms.

The objective of this study is to compare the performance of the SEND-PD with the corresponding items of the MDS-UPDRS part IA.

Methods.

Patients with Parkinson’s disease were evaluated using the MDS-UPDRS and the SEND-PD by independent raters.

Partial SEND-PD and neuropsychiatric MDS-UPDRS part IA were constructed with equivalent items for comparison.

Results.

A total of 260 consecutive patients were included.

Overall, 61.2% of the patients did not report any psychotic symptom and 83.5% did not report any ICD symptom.

On the other hand, 78.5% of the patients did report at least one symptom related to apathy, depression, or anxiety.

The partial SEND-PD score was 2.9 ± 3.1 (range from 0 to 16).

The neuropsychiatric MDS-UPDRS part IA score was 2.9 ± 3 (range from 0 to 14).

The correlation coefficient between corresponding items ranged from 0.67 to 0.98 and between both summary indexes was r s = 0.93 (all, P < 0.001 ).

Conclusion.

A high association between equivalent items of the SEND-PD and the MDS-UPDRS was found.