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Effect of Centella asiatica Leaf Extract on the Dietary Supplementation in Transgenic Drosophila Model of Parkinson’s Disease
Joint Authors
Siddique, Yasir Hasan
Fatima, Ambreen
Ali, Fahad
Mujtaba, Syed Faiz
Faisal, Mohammad
Khanam, Saba
Jyoti, Smita
Naz, Falaq
Rahul,
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The role of Centella asiatica L.
leaf extract was studied on the transgenic Drosophila model flies expressing normal human alpha synuclein (h-αS) in the neurons.
The leaf extract was prepared in acetone and was subjected to GC-MS analysis.
C.
asiatica extract at final concentration of 0.25, 0.50, and 1.0 μL/mL was mixed with the diet and the flies were allowed feeding on it for 24 days.
The effect of extract was studied on the climbing ability, activity pattern, lipid peroxidation, protein carbonyl content, glutathione content, and glutathione-S-transferase activity in the brains of transgenic Drosophila.
The exposure of extract to PD model flies results in a significant delay in the loss of climbing ability and activity pattern and reduced the oxidative stress ( P < 0.05 ) in the brains of PD flies as compared to untreated PD flies.
The results suggest that C.
asiatica leaf extract is potent in reducing the PD symptoms in transgenic Drosophila model of Parkinson’s disease.
American Psychological Association (APA)
Siddique, Yasir Hasan& Naz, Falaq& Jyoti, Smita& Fatima, Ambreen& Khanam, Saba& Rahul,…[et al.]. 2014. Effect of Centella asiatica Leaf Extract on the Dietary Supplementation in Transgenic Drosophila Model of Parkinson’s Disease. Parkinson’s Disease،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047202
Modern Language Association (MLA)
Siddique, Yasir Hasan…[et al.]. Effect of Centella asiatica Leaf Extract on the Dietary Supplementation in Transgenic Drosophila Model of Parkinson’s Disease. Parkinson’s Disease No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1047202
American Medical Association (AMA)
Siddique, Yasir Hasan& Naz, Falaq& Jyoti, Smita& Fatima, Ambreen& Khanam, Saba& Rahul,…[et al.]. Effect of Centella asiatica Leaf Extract on the Dietary Supplementation in Transgenic Drosophila Model of Parkinson’s Disease. Parkinson’s Disease. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047202
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047202