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Effect of PAH Specific Therapy on Pulmonary Hemodynamics and Six-Minute Walk Distance in Portopulmonary Hypertension: A Systematic Review and Meta-Analysis
Joint Authors
Shujaat, Adil
Faisal, Muhammad
Siddiqi, Furqan
Bajwa, Abubakr A.
Alkaddour, Ahmad
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Little is known about the effect of pulmonary arterial hypertension (PAH) specific therapy on pulmonary hemodynamics and exercise capacity in patients with portopulmonary hypertension (PoPH) because such patients are usually excluded from randomized clinical trials (RCT) of such therapy.
Methods.
We searched PUBMED using the terms “(Therapy/Broad (filter)) AND (portopulmonary hypertension).” We included studies that met the following criteria: ≥5 patients, AND PoPH confirmed by right heart catheterization (RHC), AND follow-up RHC data, AND/OR baseline and follow-up 6MWD available.
Results.
12 studies met our inclusion criteria.
None was a RCT.
The baseline mPAP was 48.6 ± 4.4 mmHg, cardiac output (CO) 5.6 ± 0.9 L/min, and pulmonary vascular resistance (PVR) 668.6 ± 219.1 dynes.sec/cm5.
The baseline 6MWD was 348.2 ± 35.6 meters.
The use of PAH specific therapy improved mPAP by 7.54 mmHg (95% CI 10.2 to 4.9), CO by 1.77 L/min (95% CI 1.1 to 2.4), and PVR by 253 dynes.sec/cm5 (95% CI 291.4 to 214.6) ( n = 135 ) and 6MWD by 61.8 meters (95% CI 47.5 to 76) ( n = 122 ).
Conclusions.
The use of PAH specific therapy in PoPH results in significant improvement in both pulmonary hemodynamics and 6MWD.
American Psychological Association (APA)
Faisal, Muhammad& Siddiqi, Furqan& Alkaddour, Ahmad& Bajwa, Abubakr A.& Shujaat, Adil. 2014. Effect of PAH Specific Therapy on Pulmonary Hemodynamics and Six-Minute Walk Distance in Portopulmonary Hypertension: A Systematic Review and Meta-Analysis. Pulmonary Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047251
Modern Language Association (MLA)
Faisal, Muhammad…[et al.]. Effect of PAH Specific Therapy on Pulmonary Hemodynamics and Six-Minute Walk Distance in Portopulmonary Hypertension: A Systematic Review and Meta-Analysis. Pulmonary Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1047251
American Medical Association (AMA)
Faisal, Muhammad& Siddiqi, Furqan& Alkaddour, Ahmad& Bajwa, Abubakr A.& Shujaat, Adil. Effect of PAH Specific Therapy on Pulmonary Hemodynamics and Six-Minute Walk Distance in Portopulmonary Hypertension: A Systematic Review and Meta-Analysis. Pulmonary Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047251