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Effects of Inactivated Bordetella pertussis on Phosphodiesterase in the Lung of Ovalbumin Sensitized and Challenged Rats
Joint Authors
Wang, Ya-Juan
Song, Shun-De
Chen, Jun-Chun
Wang, Xue-Feng
Jiang, Ya-Li
Xie, Qiang-Min
Chen, Ji-Qiang
Li, Zi-Gang
Tang, Hui-Fang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This paper indicated that inactivated Bordetella pertussis (iBp) can enhance the lung airway hyperreactivity of the rats sensitized and challenged with OVA.
The mechanisms were involved in the upregulation of cAMP-PDE activity and PDE4A, PDE4D, and PDE3 gene expression in the lungs.
But only PDE4 activity was different between the OVA and OVA+iBp groups, and PDE4D expression was significantly increased in iBp rats alone.
So, our data suggested that cosensitization with OVA and iBp affects lung airway reactivity by modulating the lung cAMP-PDE activity and PDE4D gene expression.
American Psychological Association (APA)
Wang, Ya-Juan& Song, Shun-De& Chen, Jun-Chun& Wang, Xue-Feng& Jiang, Ya-Li& Xie, Qiang-Min…[et al.]. 2014. Effects of Inactivated Bordetella pertussis on Phosphodiesterase in the Lung of Ovalbumin Sensitized and Challenged Rats. Pulmonary Medicine،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047252
Modern Language Association (MLA)
Wang, Ya-Juan…[et al.]. Effects of Inactivated Bordetella pertussis on Phosphodiesterase in the Lung of Ovalbumin Sensitized and Challenged Rats. Pulmonary Medicine No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1047252
American Medical Association (AMA)
Wang, Ya-Juan& Song, Shun-De& Chen, Jun-Chun& Wang, Xue-Feng& Jiang, Ya-Li& Xie, Qiang-Min…[et al.]. Effects of Inactivated Bordetella pertussis on Phosphodiesterase in the Lung of Ovalbumin Sensitized and Challenged Rats. Pulmonary Medicine. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047252