Radix Astragali Improves Dysregulated Triglyceride Metabolism and Attenuates Macrophage Infiltration in Adipose Tissue in High-Fat Diet-Induced Obese Male Rats through Activating mTORC1-PPARγ Signaling Pathway
Joint Authors
Long, Yang
Zhang, Xiang-Xun
Chen, Tao
Gao, Yun
Tian, Hao-Ming
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Increased levels of free fatty acids (FFAs) and hypertriglyceridemia are important risk factors for cardiovascular disease.
The effective fraction isolated from radix astragali (RA) has been reported to alleviate hypertriglyceridemia.
The mechanism of this triglyceride-lowering effect of RA is unclear.
Here, we tested whether activation of the mTORC1-PPARγ signaling pathway is related to the triglyceride-lowering effect of RA.
High-fat diet-induced obese (DIO) rats were fed a high-fat diet (40% calories from fat) for 9-10 weeks, and 4 g/kg/d RA was administered by gavage.
RA treatment resulted in decreased fasting triglyceride levels, FFA concentrations, and adipocyte size.
RA treated rats showed improved triglyceride clearance and fatty acid handling after olive oil overload.
RA administration could also decrease macrophage infiltration and expression of MCP-1 and TNFα, but it may also increase the expression of PPARγ in epididymal adipose tissue from RA treated rats.
Consistently, expressions of PPARγ and phospho-p70S6K were increased in differentiated 3T3-L1 adipocytes treated with RA.
Moreover, RA couldnot upregulate the expression of PPARγ at the presence of rapamycin.
In conclusion, the mTORC1-PPARγ signaling pathway is a potential mechanism through which RA exerts beneficial effects on the disturbance of triglyceride metabolism and dysfunction of adipose tissue in DIO rats.
American Psychological Association (APA)
Long, Yang& Zhang, Xiang-Xun& Chen, Tao& Gao, Yun& Tian, Hao-Ming. 2014. Radix Astragali Improves Dysregulated Triglyceride Metabolism and Attenuates Macrophage Infiltration in Adipose Tissue in High-Fat Diet-Induced Obese Male Rats through Activating mTORC1-PPARγ Signaling Pathway. PPAR Research،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047268
Modern Language Association (MLA)
Long, Yang…[et al.]. Radix Astragali Improves Dysregulated Triglyceride Metabolism and Attenuates Macrophage Infiltration in Adipose Tissue in High-Fat Diet-Induced Obese Male Rats through Activating mTORC1-PPARγ Signaling Pathway. PPAR Research No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047268
American Medical Association (AMA)
Long, Yang& Zhang, Xiang-Xun& Chen, Tao& Gao, Yun& Tian, Hao-Ming. Radix Astragali Improves Dysregulated Triglyceride Metabolism and Attenuates Macrophage Infiltration in Adipose Tissue in High-Fat Diet-Induced Obese Male Rats through Activating mTORC1-PPARγ Signaling Pathway. PPAR Research. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047268