PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting
Joint Authors
Wojtkowska, Izabela
Tysarowski, Andrzej
Seliga, Katarzyna
Juraszyński, Zbigniew
Marona, Milosz
Greszata, Lidia
Skrobisz, Anna
Kaminski, Karol
Sawicki, Robert
Stępińska, Janina
Siedlecki, Janusz A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Genetic research has elucidated molecular mechanisms of heart failure (HF).
Peroxisome proliferator-activated receptors (PPARs) seem to be important in etiology of HF.
The aim of study was to find the correlation between PPAR γ expression during development of HF in patients and coronary artery disease (CAD) after coronary artery bypass-grafting (CABG).
Methods and Results.
We followed up 157 patients (mean age 63) with CAD without clinical, laboratory, or echo parameters of HF who underwent CABG.
Clinical and laboratory status were assessed before CABG and at 1, 12, and 24 months.
During CABG slices of aorta (Ao) and LV were collected for genetic research.
HF was defined as LVEF <40% or NT-proBNP >400 pg/mL or 6MWT <400 m.
Patients were divided into 2 groups: with and without HF.
PPAR γ expression in Ao and LV was not increased in both groups at 2-year follow-up.
Sensitivity of PPAR γ expression in Ao above 1.1075 in detection of HF was 20.5% (AUC 0.531, 95% CI 0.442–0.619).
Positive predictive value (Ppv) was 85.7%.
Sensitivity and specificity of PPAR γ expression in the LV in detection of HF were 58% and 92.9%, respectively (AUC 0.540, 95% CI 0.452–0.626).
Ppv was 73.2%.
Conclusion.
PPAR γ expression in Ao and LV was comparable and should not be used as predictive factor for development of HF in patients with CAD after CABG.
American Psychological Association (APA)
Wojtkowska, Izabela& Tysarowski, Andrzej& Seliga, Katarzyna& Siedlecki, Janusz A.& Juraszyński, Zbigniew& Marona, Milosz…[et al.]. 2014. PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting. PPAR Research،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1047270
Modern Language Association (MLA)
Wojtkowska, Izabela…[et al.]. PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting. PPAR Research No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1047270
American Medical Association (AMA)
Wojtkowska, Izabela& Tysarowski, Andrzej& Seliga, Katarzyna& Siedlecki, Janusz A.& Juraszyński, Zbigniew& Marona, Milosz…[et al.]. PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting. PPAR Research. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1047270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047270