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Role of PPAR γ in the Differentiation and Function of Neurons
Joint Authors
Quintanilla, Rodrigo A.
Utreras, Elias
Cabezas-Opazo, Fabián A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Neuronal processes (neurites and axons) have an important role in brain cells communication and, generally, they are damaged in neurodegenerative diseases.
Recent evidence has showed that the activation of PPARγ pathway promoted neuronal differentiation and axon polarity.
In addition, activation of PPARγ using thiazolidinediones (TZDs) prevented neurodegeneration by reducing neuronal death, improving mitochondrial function, and decreasing neuroinflammation in neuropathic pain.
In this review, we will discuss important evidence that supports a possible role of PPARγ in neuronal development, improvement of neuronal health, and pain signaling.
Therefore, activation of PPARγ is a potential target with therapeutic applications against neurodegenerative disorders, brain injury, and pain regulation.
American Psychological Association (APA)
Quintanilla, Rodrigo A.& Utreras, Elias& Cabezas-Opazo, Fabián A.. 2014. Role of PPAR γ in the Differentiation and Function of Neurons. PPAR Research،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047296
Modern Language Association (MLA)
Quintanilla, Rodrigo A.…[et al.]. Role of PPAR γ in the Differentiation and Function of Neurons. PPAR Research No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047296
American Medical Association (AMA)
Quintanilla, Rodrigo A.& Utreras, Elias& Cabezas-Opazo, Fabián A.. Role of PPAR γ in the Differentiation and Function of Neurons. PPAR Research. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047296