Aberrant Hedgehog Signaling and Clinical Outcome in Osteosarcoma
Joint Authors
Wunder, Jay S.
Lo, Winnie W.
Pinnaduwage, Dushanthi
Gokgoz, Nalan
Andrulis, Irene L.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Despite the importance of Hedgehog signaling in bone development, the relationship between Hedgehog pathway expression and osteosarcoma clinical characteristics and outcome has not been investigated.
In this study of 43 high-grade human osteosarcoma samples, we detected high expression levels of the Hedgehog ligand gene, IHH, and target genes, PTCH1 and GLI1, in most samples.
Further analysis in tumors of patients with localized disease at diagnosis identified coexpression of IHH and PTCH1 exclusively in large tumors.
Higher levels of IHH were observed more frequently in males and patients with higher levels of GLI1 were more responsive to chemotherapy.
Subgroup analysis by tumor size and IHH expression indicated that the well-known association between survival and tumor size was further refined when IHH levels were taken into consideration.
American Psychological Association (APA)
Lo, Winnie W.& Pinnaduwage, Dushanthi& Gokgoz, Nalan& Wunder, Jay S.& Andrulis, Irene L.. 2014. Aberrant Hedgehog Signaling and Clinical Outcome in Osteosarcoma. Complexity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047442
Modern Language Association (MLA)
Lo, Winnie W.…[et al.]. Aberrant Hedgehog Signaling and Clinical Outcome in Osteosarcoma. Complexity Vol. 2014, no. 2014 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1047442
American Medical Association (AMA)
Lo, Winnie W.& Pinnaduwage, Dushanthi& Gokgoz, Nalan& Wunder, Jay S.& Andrulis, Irene L.. Aberrant Hedgehog Signaling and Clinical Outcome in Osteosarcoma. Complexity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047442
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047442