Stereotactic Body Radiotherapy for Metastatic and Recurrent Ewing Sarcoma and Osteosarcoma
Joint Authors
Brown, Lindsay C.
Lester, Rachael A.
Grams, Michael P.
Haddock, Michael G.
Olivier, Kenneth R.
Arndt, Carola A. S.
Rose, Peter S.
Laack, Nadia N. Issa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Radiotherapy has been utilized for metastatic and recurrent osteosarcoma and Ewing sarcoma (ES), in order to provide palliation and possibly prolong overall or progression-free survival.
Stereotactic body radiotherapy (SBRT) is convenient for patients and offers the possibility of increased efficacy.
We report our early institutional experience using SBRT for recurrent and metastatic osteosarcoma and Ewing sarcoma.
Methods.
We reviewed all cases of osteosarcoma or ES treated with SBRT between 2008 and 2012.
Results.
We identified 14 patients with a total of 27 lesions from osteosarcoma ( n = 19 ) or ES ( n = 8 ) .
The median total curative/definitive SBRT dose delivered was 40 Gy in 5 fractions (range, 30–60 Gy in 3–10 fractions).
The median total palliative SBRT dose delivered was 40 Gy in 5 fractions (range, 16–50 Gy in 1–10 fractions).
Two grade 2 and 1 grade 3 late toxicities occurred, consisting of myonecrosis, avascular necrosis with pathologic fracture, and sacral plexopathy.
Toxicity was seen in the settings of concurrent chemotherapy and reirradiation.
Conclusions.
This descriptive report suggests that SBRT may be a feasible local treatment option for patients with osteosarcoma and ES.
However, significant toxicity can result, and thus systematic study is warranted to clarify efficacy and characterize long-term toxicity.
American Psychological Association (APA)
Brown, Lindsay C.& Lester, Rachael A.& Grams, Michael P.& Haddock, Michael G.& Olivier, Kenneth R.& Arndt, Carola A. S.…[et al.]. 2014. Stereotactic Body Radiotherapy for Metastatic and Recurrent Ewing Sarcoma and Osteosarcoma. Complexity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047446
Modern Language Association (MLA)
Brown, Lindsay C.…[et al.]. Stereotactic Body Radiotherapy for Metastatic and Recurrent Ewing Sarcoma and Osteosarcoma. Complexity Vol. 2014, no. 2014 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1047446
American Medical Association (AMA)
Brown, Lindsay C.& Lester, Rachael A.& Grams, Michael P.& Haddock, Michael G.& Olivier, Kenneth R.& Arndt, Carola A. S.…[et al.]. Stereotactic Body Radiotherapy for Metastatic and Recurrent Ewing Sarcoma and Osteosarcoma. Complexity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047446