Brain Metastasis in Bone and Soft Tissue Cancers: A Review of Incidence, Interventions, and Outcomes
Joint Authors
Shweikeh, Faris
Sweiss, Fadi B.
Bukavina, Laura
Saeed, Kashif
Sarkis, Reem
Suneja, Aarushi
Drazin, Doniel G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2013), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-13
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Bone and soft tissue malignancies account for a small portion of brain metastases.
In this review, we characterize their incidence, treatments, and prognosis.
Most of the data in the literature is based on case reports and small case series.
Less than 5% of brain metastases are from bone and soft tissue sarcomas, occurring most commonly in Ewing’s sarcoma, malignant fibrous tumors, and osteosarcoma.
Mean interval from initial cancer diagnosis to brain metastasis is in the range of 20–30 months, with most being detected before 24 months (osteosarcoma, Ewing sarcoma, chordoma, angiosarcoma, and rhabdomyosarcoma), some at 24–36 months (malignant fibrous tumors, malignant peripheral nerve sheath tumors, and alveolar soft part sarcoma), and a few after 36 months (chondrosarcoma and liposarcoma).
Overall mean survival ranges between 7 and 16 months, with the majority surviving < 12 months (Ewing’s sarcoma, liposarcoma, malignant fibrous tumors, malignant peripheral nerve sheath tumors, angiosarcoma and chordomas).
Management is heterogeneous involving surgery, radiosurgery, radiotherapy, and chemotherapy.
While a survival advantage may exist for those given aggressive treatment involving surgical resection, such patients tended to have a favorable preoperative performance status and minimal systemic disease.
American Psychological Association (APA)
Shweikeh, Faris& Bukavina, Laura& Saeed, Kashif& Sarkis, Reem& Suneja, Aarushi& Sweiss, Fadi B.…[et al.]. 2014. Brain Metastasis in Bone and Soft Tissue Cancers: A Review of Incidence, Interventions, and Outcomes. Complexity،Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-1047450
Modern Language Association (MLA)
Shweikeh, Faris…[et al.]. Brain Metastasis in Bone and Soft Tissue Cancers: A Review of Incidence, Interventions, and Outcomes. Complexity Vol. 2014, no. 2014 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-1047450
American Medical Association (AMA)
Shweikeh, Faris& Bukavina, Laura& Saeed, Kashif& Sarkis, Reem& Suneja, Aarushi& Sweiss, Fadi B.…[et al.]. Brain Metastasis in Bone and Soft Tissue Cancers: A Review of Incidence, Interventions, and Outcomes. Complexity. 2014. Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-1047450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047450